ArticleACS chemical neuroscience2017
Stochastic Simulation of Dopamine Neuromodulation for Implementation of Fluorescent Neurochemical Probes in the Striatal Extracellular Space.
Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum.eLife · 2026Article
- LUHMES Cells: Phenotype Refinement and Development of an MPPInternational journal of molecular sciences · 2023Article
- The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons.Frontiers in cellular neuroscience · 2022Article
- The critical balance between dopamine D2 receptor and RGS for the sensitive detection of a transient decay in dopamine signal.PLoS computational biology · 2021Article
- Near-infrared catecholamine nanosensors for high spatiotemporal dopamine imaging.Nature protocols · 2021Review
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
- Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Corona Exchange Dynamics on Carbon Nanotubes by Multiplexed Fluorescence Monitoring.Journal of the American Chemical Society · 2020Article
- High-throughput evolution of near-infrared serotonin nanosensors.Science advances · 2019Article
- Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor.Science advances · 2019Article
- Review Article: Tools and trends for probing brain neurochemistry.Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society · 2019Review
- Synthetic probe development for measuring single or few-cell activity and efflux.Methods in enzymology · 2019Article
- Ultralarge Modulation of Fluorescence by Neuromodulators in Carbon Nanotubes Functionalized with Self-Assembled Oligonucleotide Rings.Nano letters · 2018Article
- Advances in Nanomaterials for Brain Microscopy.Nano research · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Imaging the dynamic behavior of neuromodulatory neurotransmitters in the extracelluar space that arise from individual quantal release events would constitute a major advance in neurochemical imaging. Spatial and temporal resolution of these highly stochastic neuromodulatory events requires concurrent advances in the chemical development of optical nanosensors selective for neuromodulators in concert with advances in imaging methodologies to capture millisecond neurotransmitter release. Herein, we develop and implement a stochastic model to describe dopamine dynamics in the extracellular space (ECS) of the brain dorsal striatum to guide the design and implementation of fluorescent neurochemical probes that record neurotransmitter dynamics in the ECS. Our model is developed from first-principles and simulates release, diffusion, and reuptake of dopamine in a 3D simulation volume of striatal tissue. We find that in vivo imaging of neuromodulation requires simultaneous optimization of dopamine nanosensor reversibility and sensitivity: dopamine imaging in the striatum or nucleus accumbens requires nanosensors with an optimal dopamine dissociation constant (K
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