ArticleAnalytical chemistry2017
Characterization of Chemical Exchange Using Relaxation Dispersion of Hyperpolarized Nuclear Spins.
Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Machine learning-assisted molecular design for efficientChemical science · 2026Article
- Quantification of Ligand-Membrane Interactions Using DNP-NMR Relaxometry.Analytical chemistry · 2026Article
- Characterization of Cell-Surface Interactions of Ligands UsingAnalytical chemistry · 2026Article
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Application of Relaxation Dispersion of HyperpolarizedAngewandte Chemie (International ed. in English) · 2021Article
- Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarizedChemical science · 2020Article
- Applications of Dissolution-DNP for NMR Screening.Methods in enzymology · 2019Article
- Determination of binding affinities using hyperpolarized NMR with simultaneous 4-channel detection.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
Chemical exchange phenomena are ubiquitous in macromolecules, which undergo conformational change or ligand complexation. NMR relaxation dispersion (RD) spectroscopy based on a Carr-Purcell-Meiboom-Gill pulse sequence is widely applied to identify the exchange and measure the lifetime of intermediate states on the millisecond time scale. Advances in hyperpolarization methods improve the applicability of NMR spectroscopy when rapid acquisitions or low concentrations are required, through an increase in signal strength by several orders of magnitude. Here, we demonstrate the measurement of chemical exchange from a single aliquot of a ligand hyperpolarized by dissolution dynamic nuclear polarization (D-DNP). Transverse relaxation rates are measured simultaneously at different pulsing delays by dual-channel
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