Evidence map›Paper›PMID 28714611›Full record

ReviewPediatric pulmonology2017

Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers.

Olivia Giddings, Charles R Esther

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric pulmonology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Cellular imbalance in proximal and distal lung of CFTRMolecular medicine (Cambridge, Mass.) · 2025
    Article
  3. Review
  4. Review
  5. Metabolomics of airways disease in cystic fibrosis.Current opinion in pharmacology · 2022
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Olivia GiddingsPulmonology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Charles R EstherPediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID http://orcid.org/0000-0002-8081-2986
University of North Carolina at Chapel Hill · US

Funding

Mucus and hypoxia in heterogeneous and progressive CF lung diseaseR01HL116228 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ESTHER, CHARLES RICHARD, MUHLEBACH, MARIANNE S · 2012 to 2015
$2.1M
Purines as Biomarkers of Respiratory DiseaseK23HL089708 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ESTHER, CHARLES RICHARD · 2009 to 2013
$685k
NHLBI NIH HHS K23 HL089708NHLBI NIH HHS R01 HL116228
6 · The paper itself

Abstract

Cystic fibrosis is characterized by an overly exuberant neutrophilic inflammatory response to pathogens and other stimuli that starts very early in disease. The overwhelming nature of this response is a primary cause of remodeling and destruction of the airways, suggesting that anti-inflammatory therapies could be beneficial in CF. However, finding therapies that can effectively reduce the inflammatory response without compromising host defenses remains elusive. New approaches towards mapping inflammatory targets promise to aid in developing novel therapeutic strategies and improve outcomes in individuals with CF.

Indexed as

AnimalsAnti-Inflammatory AgentsBiomarkersCystic FibrosisHumansInflammationAnti-Inflammatory AgentsBiomarkersbronchoalveolar lavageexhaled breath condensatemetabolomicsSputum

Identifiers

PMID28714611
PMCPMC5664212
OpenAlexW2734676785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.