ArticleHuman brain mapping2017
MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed.
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Review
- Somatosensory dysfunction is masked by variable cognitive deficits across patients on the Alzheimer's disease spectrum.EBioMedicine · 2021Article
- Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy.Journal of Alzheimer's disease reports · 2021Article
- Decoding expectation and surprise in dementia: the paradigm of music.Brain communications · 2021Article
- Triple model of auditory sensory processing: a novel gating stream directly links primary auditory areas to executive prefrontal cortex.Acta clinica Croatica · 2020Review
- Fusion of ULS Group Constrained High- and Low-Order Sparse Functional Connectivity Networks for MCI Classification.Neuroinformatics · 2020Article
- Dysfunction of Inferior Parietal Lobule During Sensory Gating in Patients With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- Attention modulates topology and dynamics of auditory sensory gating.Human brain mapping · 2019Article
- IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Review
- A Comprehensive Review of Magnetoencephalography (MEG) Studies for Brain Functionality in Healthy Aging and Alzheimer's Disease (AD).Frontiers in computational neuroscience · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Magnetoencephalography (MEG), a direct measure of neuronal activity, is an underexplored tool in the search for biomarkers of Alzheimer's disease (AD). In this study, we used MEG source estimates of auditory gating generators, nonlinear correlations with neuropsychological results, and multivariate analyses to examine the sensitivity and specificity of gating topology modulation to detect AD. Our results demonstrated the use of MEG localization of a medial prefrontal (mPFC) gating generator as a discrete (binary) detector of AD at the individual level and resulted in recategorizing the participant categories in: (1) controls with mPFC generator localized in response to both the standard and deviant tones; (2) a possible preclinical stage of AD participants (a lower functioning group of controls) in which mPFC activation was localized to the deviant tone only; and (3) symptomatic AD in which mPFC activation was not localized to either the deviant or standard tones. This approach showed a large effect size (0.9) and high accuracy, sensitivity, and specificity (100%) in identifying symptomatic AD patients within a limited research sample. The present results demonstrate high potential of mPFC activation as a noninvasive biomarker of AD pathology during putative preclinical and clinical stages. Hum Brain Mapp 38:5180-5194, 2017. © 2017 Wiley Periodicals, Inc.
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