Evidence map›Paper›PMID 28714557›Full record

ReviewStem cells translational medicine2017

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles.

Agnes T Reiner, Kenneth W Witwer, Bas W M van Balkom, Joel de Beer, Chaya Brodie, Randolph L Corteling, Susanne Gabrielsson, Mario Gimona, Ahmed G Ibrahim, Dominique de Kleijn and 16 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Stem cell extracellular vesicles for neuropsychiatric disorders and translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Agnes T ReinerBioSensor Technologies, AIT Austrian Institute of Technology, Vienna, Austria.ORCID 0000-0002-7077-1199
Kenneth W WitwerDepartments of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bas W M van BalkomDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Joel de BeerAnjarium Biosciences AG, Zollikon, Switzerland.
Chaya BrodieDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.
Randolph L CortelingReNeuron Group, Pencoed, United Kingdom.
Susanne GabrielssonDepartment of Medicine, Unit for Immunology and Allergy, Karolinska Institute, Stockholm, Sweden.
Mario GimonaSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
Ahmed G IbrahimCapricor Therapeutics, Los Angeles, California, USA.
Dominique de KleijnDept. of Vascular Surgery & Cardiology, Utrecht University, Utrecht, The Netherlands.
Charles P LaiInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.
Jan LötvallKrefting Research Centre, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Hernando A Del PortilloICREA at ISGlobal Barcelona Institute for Global Health, Ctr. Int. Health Res. (CRESIB), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Ilona G ReischlFederal Office for Safety in Health Care, Institute Surveillance, Vienna, Austria.
Milad RiazifarDepartment of Pharmaceutical Sciences, University of California, Irvine, California, USA.
Carlos SalomonCentre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Australia.
Hidetoshi TaharaDepartment of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Wei Seong TohFaculty of Dentistry, National University of Singapore, Singapore.
Marca H M WaubenDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Vicky K YangDepartment of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA.
Yijun YangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Ronne Wee Yeh YeoInstitute of Medical Biology, A*STAR, Singapore.
Hang YinDepartment of Chemistry and Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA.
Bernd GiebelInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Germany.
Eva RohdeSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
Sai Kiang LimInstitute of Medical Biology, A*STAR, Singapore.

Funding

Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine AbuseR01DA040385 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2015 to 2019
$2.3M
NIDA NIH HHS R01 DA040385
6 · The paper itself

Abstract

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730-1739.

Indexed as

Congresses as TopicPractice Guidelines as TopicAnimalsCell TransplantationExtracellular VesiclesHumansSingaporeTranslational Research, BiomedicalCellular therapyClinical translationClinical trialsExosomesExtracellular vesiclesMicrovesiclesStem cellsTherapeutics

Identifiers

PMID28714557
PMCPMC5689784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.