Evidence map›Paper›PMID 28714469›Full record

ArticleNature communications2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Carl D Langefeld, Hannah C Ainsworth, Deborah S Cunninghame Graham, Jennifer A Kelly, Mary E Comeau, Miranda C Marion, Timothy D Howard, Paula S Ramos, Jennifer A Croker, David L Morris and 98 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

108 authors.

Carl D LangefeldCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Hannah C AinsworthCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Deborah S Cunninghame GrahamDivisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.
Jennifer A KellyArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Mary E ComeauCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Miranda C MarionCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Timothy D HowardCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Paula S RamosDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Jennifer A CrokerDivision of Clinical Immunology and Rheumatology, UAB School of Medicine, Birmingham, Alabama 35294, USA.ORCID 0000-0002-6292-4132
David L MorrisDivisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.
Johanna K SandlingDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala 752 36, Sweden.
Jonas Carlsson AlmlöfDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala 752 36, Sweden.
Eduardo M Acevedo-VásquezDepartamento de Reumatología, Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima 15081, Perú.
Graciela S AlarcónDivision of Clinical Immunology and Rheumatology, UAB School of Medicine, Birmingham, Alabama 35294, USA.
Alejandra M BabiniHospital Italiano de Córdoba, Córdoba X5004BAL, Argentina.
Vicente BacaHospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Anders A BengtssonDepartment of Clinical Sciences, Rheumatology, Lund University, Lund 22362, Sweden.
Guillermo A BerbottoHospital Eva Perón, Granadero Baigorria S2152EDD, Argentina.
Marc BijlDepartment of Internal Medicine and Rheumatology, Martini Hospital, Van Swietenplein 1, 9728, NT, Groningen, The Netherlands.
Elizabeth E BrownDivision of Clinical Immunology and Rheumatology, UAB School of Medicine, Birmingham, Alabama 35294, USA.
Hermine I BrunnerDivision of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.
Mario H CardielCentro de Investigación Clínica de Morelia, Morelia, Michoacán 58070, Mexico.
Luis CatoggioHospital Italiano de Buenos Aires, 1181, Buenos Aires C1181ACH, Argentina.ORCID 0000-0002-4047-4863
Ricard CerveraDepartment of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Barcelona, Catalonia 08007, Spain.
Jorge M Cucho-VenegasDepartamento de Reumatología, Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima 15081, Perú.
Solbritt Rantapää DahlqvistDepartment of Public Health and Clinical Medicine, Division of Rheumatology, Umeå University, Umeå 901 87, Sweden.
Sandra D'AlfonsoDepartment of Health Sciences and Institute of Research in Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara 28100, Italy.
Berta Martins Da SilvaUnidade Multidisciplinar em Investigação Biomédica/Instituto de Ciências Biomédicas de Abel Salazar-Universidade do Porto, Porto 4099-003, Portugal.
Iñigo de la Rúa FigueroaDepartment of Rheumatology, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria 35010, Spain.
Andrea DoriaDivision of Rheumatology, Department of Medicine (DIMED), University of Padua, Padua 35122, Italy.
Jeffrey C EdbergDivision of Clinical Immunology and Rheumatology, UAB School of Medicine, Birmingham, Alabama 35294, USA.
Emőke EndreffyDepartment of Pediatrics and Child Health Center, Albert Szent-Györgyi Medical Center, Faculty of Medicine, University of Szeged, Szeged H-6720, Hungary.
Jorge A Esquivel-ValerioHospital Universitario 'Dr José Eleuterio González' Universidad Autonoma de Nuevo León, Monterrey 64020, México.
Paul R FortinCHU de Québec Université Laval, Québec, Canada G1R 2JG.
Barry I FreedmanCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Johan FrostegårdInstitute of Environmental Medicine, Unit of Immunology and Chronic diseases, Karolinska Institutet, Stockholm 171 77, Sweden.
Mercedes A GarcíaDivision of Rheumatology, Hospital Interzonal General de Agudos General San Martín, La Plata 1900, Argentina.
Ignacio García de la TorreUniversity of Guadalajara, Departamento de Fisiología, Guadalajara, Jalisco 44100, Mexico.
Gary S GilkesonDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Dafna D GladmanCentre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada.
Iva GunnarssonUnit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
Joel M GuthridgeArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Jennifer L HugginsDivision of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.
Judith A JamesArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Cees G M KallenbergDepartment of Rheumatology and Clinical Immunology,University Medical Center Groningen,University of Groningen, Groningen 9713 GZ, The Netherlands.
Diane L KamenDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
David R KarpDepartment of Immunology, University of Texas SouthWestern Medical Center, Dallas, Texas 75235, USA.
Kenneth M KaufmanDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Leah C KottyanDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.ORCID 0000-0003-3979-2220
László KovácsDepartment of Rheumatology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged H-6720, Hungary.
Helle LaustrupDepartment of Rheumatology, Odense University Hospital, Odense 5000, Denmark.
Bernard R LauwerysRheumatology, Cliniques Universitaires Saint-Luc &Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Louvain-la-Neuve 1348, Belgium.
Quan-Zhen LiDepartment of Immunology, University of Texas SouthWestern Medical Center, Dallas, Texas 75235, USA.
Marco A Maradiaga-CeceñaHospital General de Culiacán, Sinaloa 80220, Mexico.
Javier MartínInstituto de Parasitología y Biomedicina López Neyra, CSIC, Granada 18100, Spain.
Joseph M McCuneUniversity of Michigan Medical Center, Ann Arbor, Michigan 48103, USA.
David R McWilliamsCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Joan T MerrillArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Pedro MirandaCentro de Estudios Reumatológicos, Santiago de Chile, Santiago 7500000, Chile.
José F MoctezumaDepartamento de Reumatología, Hospital General de México, Mexico D.F., Mexico.
Swapan K NathArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Timothy B NiewoldDepartment of Rheumatology, Mayo Clinic, Rochester, Minnesota 94158, USA.
Lorena OrozcoInstituto Nacional de Medicina Genómica (INMEGEN), México City 14610, México.
Norberto Ortego-CentenoUnidad de Enfermedades Autoimmunes Sistémicas, UGC Medicina Interna, Hospital Universitario San Cecilio, Granada 18007, Spain.
Michelle PetriDivision of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA.
Christian A PineauRheumatology Division, McGill University, Montreal, Quebec H3A 0G4, Canada.
Bernardo A Pons-EstelDepartment of Rheumatology, Sanatorio Parque, Rosario S2000, Argentina.
Janet PopeUniversity of Western Ontario, London, Ontario, Canada M5T 2S8.
Prithvi RajDepartment of Immunology, University of Texas SouthWestern Medical Center, Dallas, Texas 75235, USA.
Rosalind Ramsey-GoldmanDivision of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
John D ReveilleThe University of Texas Health Science Center at Houston (UTHealth) Medical School, Houston, Texas 77030, USA.
Laurie P RussellCenter for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
José M SabioHospital Universitario Virgen de las Nieves, Granada 18014, Spain.
Carlos A Aguilar-SalinasInstituto Nacional de Ciencias Médicas y Nutrición, Department of Endocrinology and Metabolism, Vasco de Quiroga 15, Mexico City 14080, Mexico.
Hugo R ScherbarthUnidad Reumatología y Enfermedades Autoinmunes H.I.G.A. Dr Alende Mar del Plata, Buenos Aires B7600, Argentina.
Raffaella ScorzaReferral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca'Granda Ospedale Ma Repiore Policlinico and University of Milan, Milan 20122, Italy.
Michael F SeldinDepartment of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, California 95616, USA.
Christopher SjöwallRheumatology Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping 581 83, Sweden.
Elisabet SvenungssonUnit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
Susan D ThompsonDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Sergio M A TolozaMinistry of Health, San Fernando del Valle de Catamarca, Catamarca K4700, Argentina.
Lennart TruedssonDepartment of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund 221 00, Sweden.
Teresa Tusié-LunaUnidad de Biología Molecular y Medicina Genómica Instituto de Investigaciones Biomédicas/UNAM Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Carlos VasconcelosHospital Santo Antonio, Universidade do Porto, Porto 4099-003, Portugal.
Luis M ViláUniversity of Puerto Rico School of Medicine, San Juan 00936, Puerto Rico.
Daniel J WallaceDepartment of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA.
Michael H WeismanDepartment of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA.
Joan E WitherCentre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada.
Tushar BhangaleHuman Genetics, Genentech Inc, South San Francisco, California 94080, USA.
Jorge R OksenbergDepartment of Neurology and Institute of Human Genetics, University of California at San Francisco, San Francisco, California 94158, USA.
John D RiouxUniversité de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
Peter K GregersenCenter for Genomics &Human Genetics, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
Ann-Christine SyvänenDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala 752 36, Sweden.
Lars RönnblomDepartment of Medical Sciences, Rheumatology, Uppsala University, 752 36, Sweden.
Lindsey A CriswellRosalind Russell/Ephraim P Engleman Rheumatology Research Center, Division of Rheumatology, UCSF School of Medicine, San Francisco, California 94158, USA.
Chaim O JacobKeck School of Medicine of USC, Los Angeles, California 90033, USA.
Kathy L SivilsArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Betty P TsaoDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Laura E SchanbergDepartment of Pediatrics, Duke University, Durham, North Carolina 27708, USA.
Timothy W BehrensHuman Genetics, Genentech Inc, South San Francisco, California 94080, USA.
Earl D SilvermanDepartment of Pediatrics and the Institute of Medical Sciences, The Hospital for Sick Children, Hospital for Sick Children Research Institute and University of Toronto, Ontario, Canada M5G 1X8.
Marta E Alarcón-RiquelmeArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Robert P KimberlyDivision of Clinical Immunology and Rheumatology, UAB School of Medicine, Birmingham, Alabama 35294, USA.
John B HarleyDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Edward K WakelandDepartment of Immunology, University of Texas SouthWestern Medical Center, Dallas, Texas 75235, USA.
Robert R GrahamHuman Genetics, Genentech Inc, South San Francisco, California 94080, USA.
Patrick M GaffneyArthritis &Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
Timothy J VyseDivisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PAUL G SPICER · 2013 to 2026
$68.2M
Pediatric Rheumatology Tissue RepostoryP01AR048929 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI THOMPSON, SUSAN D · 2003 to 2015
$13.6M
Program Project in the Genetics of SLEP01AR049084 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2002 to 2012
$12.7M
The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
SOUTH CAROLINA CLINICAL & TRANSLATIONAL RESEARCH INSTITUTE (SCTR)UL1RR029882 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2009 to 2011
$10.1M
SequencingP01AI083194 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KIMBERLY, ROBERT P. · 2009 to 2013
$9.6M
ROLE OF ANGPTL4, AN ANGIOGENIC MEDIATOR, IN ARTHRITISP30AR047363 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI FLICK, MATTHEW J. · 2001 to 2015
$9.2M
Resource CoreP30AR072582 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JAMES C OATES · 2017 to 2026
$8.5M
SLAM Genes-from Mouse to ManP50AR055503 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI KARP, DAVID R · 2007 to 2011
$8.3M
Lupus CohortR01AR043727 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 1997 to 2015
$8.2M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
NCATS NIH HHS U54 TR001018NCI NIH HHS R01 CA141700NCRR NIH HHS UL1 RR029882NIAID NIH HHS P01 AI083194NIAID NIH HHS R21 AI107176NIAID NIH HHS U01 AI101934NIAID NIH HHS U19 AI082714NIAMS NIH HHS K01 AR067280NIAMS NIH HHS N01 AR022265NIAMS NIH HHS P01 AR048929NIAMS NIH HHS P01 AR049084NIAMS NIH HHS P30 AR047363NIAMS NIH HHS P30 AR053483NIAMS NIH HHS P30 AR070155NIAMS NIH HHS P30 AR070549NIAMS NIH HHS P30 AR072582NIAMS NIH HHS P50 AR055503NIAMS NIH HHS P60 AR053308NIAMS NIH HHS P60 AR062755NIAMS NIH HHS R01 AR043727NIAMS NIH HHS R01 AR043814NIAMS NIH HHS R01 AR056360NIAMS NIH HHS R01 AR057172NIAMS NIH HHS R01 AR060366NIAMS NIH HHS R01 AR063124NIAMS NIH HHS R21 AR065626NIAMS NIH HHS RC1 AR058621NIAMS NIH HHS RC2 AR058959NIDDK NIH HHS R01 DK107502NIGMS NIH HHS P30 GM103510NIGMS NIH HHS P30 GM110766NIGMS NIH HHS U54 GM104938NIMHD NIH HHS R01 MD007909
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P<5 × 10

Indexed as

Genetic LoadAge of OnsetAmerican Indian or Alaska NativeBlack PeopleCase-Control StudiesHispanic or LatinoHLA AntigensHumansLogistic ModelsLupus Erythematosus, SystemicMultifactorial InheritanceMutagenesis, InsertionalPolymorphism, Single NucleotideSequence DeletionWhite PeopleHLA Antigens

Identifiers

PMID28714469
PMCPMC5520018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.