Evidence map›Paper›PMID 28714356›Full record

ArticlePulmonary circulation

Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension.

Jeffrey D Marshall, Maor Sauler, Adriano Tonelli, Youlan Rao, Richard Bucala, Patty J Lee, Wassim H Fares

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Cytokines, Chemokines, and Inflammation in Pulmonary Arterial Hypertension.Advances in experimental medicine and biology · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jeffrey D Marshall1 Yale University School of Medicine, Section of Pulmonary, Critical Care, & Sleep Medicine, New Haven, CT, USA.
Maor Sauler1 Yale University School of Medicine, Section of Pulmonary, Critical Care, & Sleep Medicine, New Haven, CT, USA.
Adriano Tonelli2 Cleveland Clinic, Department of Pulmonary and Critical Care, Cleveland, OH, USA.
Youlan Rao3 United Therapeutics Corporation, Research Triangle Park, NC, USA.
Richard Bucala4 Yale University School of Medicine, Section of Rheumatology, New Haven, CT, USA.
Patty J Lee1 Yale University School of Medicine, Section of Pulmonary, Critical Care, & Sleep Medicine, New Haven, CT, USA.
Wassim H Fares1 Yale University School of Medicine, Section of Pulmonary, Critical Care, & Sleep Medicine, New Haven, CT, USA.
Yale University · USCleveland Clinic · USTriangle · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mechanisms of Rheumatoid Synovial Fibroblast ActivationR01AR049610 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2002 to 2018
$5.0M
MIF and DNA repair in the emphysematous lungK08HL135402 · NHLBI · YALE UNIVERSITY · PI SAULER, MAOR · 2017 to 2021
$842k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL135402NIAMS NIH HHS R01 AR049610
6 · The paper itself

Abstract

Macrophage migration inhibitory factor (MIF) and 22 a priori selected biomarkers were measured from pulmonary arterial hypertension (PAH) patients. Significant positive correlations were found between MIF and several angiogenic factors suggesting a possible MIF regulation role in PAH angiogenesis and pathobiology, but simultaneously highlighting the biomarkers profiling complexity in PAH.

Indexed as

angiogenesisbiomarkerpulmonary arterial hypertension

Identifiers

PMID28714356
PMCPMC5841895
OpenAlexW2737238064

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.