ArticleCell proliferation2017
Schwann cells secrete extracellular vesicles to promote and maintain the proliferation and multipotency of hDPCs.
Article in Cell proliferation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Schwann cell-derived extracellular vesicles promote periodontal tissue regeneration.Journal of nanobiotechnology · 2026Article
- Hypoxia-induced Schwann cells-derived extracellular vesicles carrying LncRNA TNXA-PS1 promote recovery post sciatic nerve injury.Communications biology · 2026Article
- An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair.International journal of oral science · 2025Article
- Extracellular vesicles derived from Schwann cells to enhance bone and dental tissue regeneration: a literature review.Journal of nanobiotechnology · 2025Review
- Regenerative endodontic therapy: From laboratory bench to clinical practice.Journal of advanced research · 2025Review
- Emerging roles of extracellular vesicles in oral and maxillofacial areas.International journal of oral science · 2025Review
- Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins.Pharmaceutics · 2025Review
- Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy.Biomolecules · 2024Review
- Crucial Factors Influencing the Involvement of Odontogenic Exosomes in Dental Pulp Regeneration.Stem cell reviews and reports · 2023Review
- Bioprinted constructs that simulate nerve-bone crosstalk to improve microenvironment for bone repair.Bioactive materials · 2023Article
- Comparative proteomic analysis of exosomes derived from endothelial cells and Schwann cells.PloS one · 2023Article
- Neural Regulations in Tooth Development and Tooth-Periodontium Complex Homeostasis: A Literature Review.International journal of molecular sciences · 2022Review
- Multidifferentiation potential of dental-derived stem cells.World journal of stem cells · 2021Review
- Extracellular Vesicles: An Emerging Regenerative Treatment for Oral Disease.Frontiers in cell and developmental biology · 2021Review
- Proteomic profiling of various human dental stem cells - a systematic review.World journal of stem cells · 2020Article
- Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration.Neural regeneration research · 2020Review
- Emerging functions and clinical applications of exosomes in human oral diseases.Cell & bioscience · 2020Review
- Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System.Stem cells international · 2018Article
- Schwann cells secrete extracellular vesicles to promote and maintain the proliferation and multipotency of hDPCs.Cell proliferation · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSchwann cells (SCs) are the principal glial cells in peripheral nerve system, involved in neuropathies with great regenerative potential. Dental pulp cells have been reported to maintain neurogenic potential. In contrast, the regulatory role of SCs on human dental pulp cells (hDPCs) development remains undefined. MATERIALS AND
methodsSC secretion and SC-derived extracellular vesicles (EVs) were collected and used to treat hDPCs; and proliferation and multiple differentiation of hDPCs were detected after EVs treatments. Finally, we analysed the proteomes of SC-EVs and SCs through mass spectrum.
resultsIn this study, we found SC secretion showed a predominantly regulatory role on the development of hDPCs. Further, we identified EVs from SC secretion with similar function as SC secretion in regulating hDPCs proliferation and multipotency. And expression of transcription factor Oct4 was upregulated after treatment of both SC secretion and EVs, as well as Sox2 and Nanog. We detected abundant enrichment of Oct4 in EVs, which might be responsible for the upregulation of stem cell-related genes in hDPCs. Through proteome and western blot analysis, we found enriched TGFβs in EVs, indicating that accelerated hDPCs proliferation may be mediated by activated TGFβ-Samd and TGFβ-MAPK signalling.
conclusionsIn summary, our study sheds light on critical regulatory ability of SC-derived EVs on hDPCs proliferation and multipotency, suggesting great implications for seeding cells used in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.