ReviewJournal of child psychology and psychiatry, and allied disciplines2018
Annual Research Review: Early adversity, the hypothalamic-pituitary-adrenocortical axis, and child psychopathology.
Review in Journal of child psychology and psychiatry, and allied disciplines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
228 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Cognitive Outcomes of Children With Complex Trauma: A Systematic Review and Meta-Analyses of Longitudinal Studies.Trauma, violence & abuse · 2023Pooled it
- Understanding the association between adverse childhood experiences and subsequent attention deficit hyperactivity disorder: A systematic review and meta-analysis of observational studies.Brain and behavior · 2022Pooled it
- Deconstructing pathways to resilience: A systematic review of associations between psychosocial mechanisms and transdiagnostic adult mental health outcomes in the context of adverse childhood experiences.Clinical psychology & psychotherapy · 2022Pooled it
- Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects.Neuroscience and biobehavioral reviews · 2022Pooled it
- The Transdiagnostic Origins of Anxiety and Depression During the Pediatric Period: Linking NIMH Research Domain Criteria (RDoC) Constructs to Ecological Systems.Development and psychopathology · 2021Pooled it
- Social buffering of the cortisol stress response during the Minnesota Imaging Stress Test in Children.Psychoneuroendocrinology · 2026Trial
- A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming.Nature communications · 2024Trial
- Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events.Development and psychopathology · 2020Trial
- Parental sensitivity mediates the sustained effect of Attachment and Biobehavioral Catch-up on cortisol in middle childhood: A randomized clinical trial.Psychoneuroendocrinology · 2020Trial
- Effectiveness of a psycho-educational intervention for expecting parents to prevent postpartum parenting stress, depression and anxiety: a randomized controlled trial.BMC pregnancy and childbirth · 2020Trial
- Comparing childhood, chronic, and recent adversity on internalizing symptoms and hypothalamic-pituitary-adrenal axis functioning.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- Early Childhood Emotional, Relational, and Stress-Related Outcomes Following Infant Cardiac Surgery.Developmental psychobiology · 2026Article
- Salivary cortisol reactivity to stress in pregnancy: A scoping review.Psychoneuroendocrinology · 2026Article
- Resilience in the early postpartum period: Buffering the impact of maternal ACEs on infant socioemotional development.Infant mental health journal · 2026Article
- Gut microbiota restructured by social isolation: Evidence for sex-specific response patterns.Brain, behavior, & immunity - health · 2026Article
- Article
- Dietary Inflammatory Index and Depressive Symptoms in Chinese University Students Leveraging an Intelligent Ordering System: 3-Year Longitudinal Prospective Cohort Study.Journal of medical Internet research · 2026Article
- Infant-mother attachment security and cortisol reactivity during the strange situation procedure: Longitudinal associations with maternal depressive symptoms and infant temperament.Neurobiology of stress · 2026Article
168 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundResearch on early adversity, stress biology, and child development has grown exponentially in recent years.
findingsWe review the current evidence for the hypothalamic-pituitary-adrenocortical (HPA) axis as a stress-mediating mechanism between various forms of childhood adversity and psychopathology. We begin with a review of the neurobiology of the axis and evidence for relations between early adversity-HPA axis activity and HPA axis activity-psychopathology, as well as discuss the role of regulatory mechanisms and sensitive periods in development.
conclusionsWe call attention to critical gaps in the literature to highlight next steps in this research including focus on developmental timing, sex differences, stress buffering, and epigenetic regulation. A better understanding of individual differences in the adversity-HPA axis-psychopathology associations will require continued work addressing how multiple biological and behavioral systems work in concert to shape development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.