Evidence map›Paper›PMID 28714048›Full record

ReviewCurrent psychiatry reports2017

Avoidant/Restrictive Food Intake Disorder: a Three-Dimensional Model of Neurobiology with Implications for Etiology and Treatment.

Jennifer J Thomas, Elizabeth A Lawson, Nadia Micali, Madhusmita Misra, Thilo Deckersbach, Kamryn T Eddy

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current psychiatry reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 5 pooled it
28.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 5 syntheses or guidelines pooled it, 355 citations in OpenAlex.

  1. Pooled it
  2. Avoidant-Restrictive Food Intake Disorder in Patients With Gastrointestinal Disorders: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital, 2 Longfellow Place, Suite 200, Boston, MA, 02114, USA. jjthomas@mgh.harvard.edu.
Elizabeth A LawsonNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Nadia MicaliEating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Madhusmita MisraPediatric Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Thilo DeckersbachDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital, 2 Longfellow Place, Suite 200, Boston, MA, 02114, USA.
Harvard University · USMassachusetts General Hospital · USChild Health and Development Institute · US

Funding

Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
NIMH NIH HHS R01 MH108595
6 · The paper itself

Abstract

purpose of reviewDSM-5 defined avoidant/restrictive food intake disorder (ARFID) as a failure to meet nutritional needs leading to low weight, nutritional deficiency, dependence on supplemental feedings, and/or psychosocial impairment. We summarize what is known about ARFID and introduce a three-dimensional model to inform research. RECENT

findingsBecause ARFID prevalence, risk factors, and maintaining mechanisms are not known, prevailing treatment approaches are based on clinical experience rather than data. Furthermore, most ARFID research has focused on children, rather than adolescents or adults. We hypothesize a three-dimensional model wherein neurobiological abnormalities in sensory perception, homeostatic appetite, and negative valence systems underlie the three primary ARFID presentations of sensory sensitivity, lack of interest in eating, and fear of aversive consequences, respectively. Now that ARFID has been defined, studies investigating risk factors, prevalence, and pathophysiology are needed. Our model suggests testable hypotheses about etiology and highlights cognitive-behavioral therapy as one possible treatment.

Indexed as

Feeding and Eating DisordersHumansAvoidant/restrictive food intake disorderEating disorderFeeding disorder

Identifiers

PMID28714048
PMCPMC6281436
OpenAlexW2734650846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.