ArticleMolecular medicine reports2017
miRNA‑1284 inhibits cell growth and induces apoptosis of lung cancer cells.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.Discover oncology · 2025Review
- CBX4/miR-190 regulatory loop inhibits lung cancer metastasis.Thoracic cancer · 2024Article
- (Nano)biotechnological approaches in the treatment of cervical cancer: integration of engineering and biology.Frontiers in immunology · 2024Review
- Plasma microRNA Profiling in Type 2 Diabetes Mellitus: A Pilot Study.International journal of molecular sciences · 2023Article
- A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer.Respiratory research · 2023Review
- The roles of microRNAs played in lung diseases via regulating cell apoptosis.Molecular and cellular biochemistry · 2021Review
- LncRNA XIST acts as a MicroRNA-520 sponge to regulate the Cisplatin resistance in NSCLC cells by mediating BAX through CeRNA network.International journal of medical sciences · 2021Article
- CD59 receptor targeted delivery of miRNA-1284 and cisplatin-loaded liposomes for effective therapeutic efficacy against cervical cancer cells.AMB Express · 2020Article
- The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1.Yonsei medical journal · 2020Article
- A five-CpG signature of microRNA methylation in non-G-CIMP glioblastoma.CNS neuroscience & therapeutics · 2019Article
- miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.Oncology research · 2019Article
- miR-423-5p inhibits the proliferation and metastasis of glioblastoma cells by targeting phospholipase C beta 1.International journal of clinical and experimental pathology · 2019Article
- miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma.Bioscience reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is the most common cancer worldwide, and morbidity and mortality associated with lung cancer has been increasing annually in recent decades. MicroRNAs (miRNAs), which are short non‑coding RNA sequences that are involved in the regulation of gene expression, have been previously demonstrated to be key regulators in cancer. The present study aimed to clarify the role of miRNA (miR)‑1284 in lung cancer. A549 lung carcinoma cells were transfected with miR‑1284 mimic or miR‑1284 inhibitor using Lipofectamine 2000. Subsequently, cell viability, growth and apoptosis of A459 cells in the miR‑1284 mimic, miR‑1284 inhibitor and control groups were assayed by MTT assay, bromodeoxyuridine assay and flow cytometry, respectively. Furthermore, the protein expression levels of p27, p21, Bax, pro‑caspase‑3, activated caspase‑3 and Myc were detected by western blot analysis to investigate the molecular mechanisms underlying the effect of miR‑1284 on A549 cells. The cell viability and growth of A549 cells were significantly decreased in the miR‑1284 mimic group compared with the control group, whereas the percentage of apoptotic cells was significantly increased. By contrast, miR‑1284 inhibitor transfection significantly increased the cell viability and growth compared with control, and decreased apoptosis. Furthermore, expression of p27 was increased in miR‑1284 mimic‑transfected A549 cells compared with the control group, whereas p21 was unaffected by miR‑1284 overexpression or inhibition. The expression of Myc was decreased by miR‑1284 mimic transfection compared with the control group. For the other apoptosis‑associated proteins that were investigated (Bax, pro‑caspase‑3 and active caspase‑3), the expression levels in the miR‑1284 mimic transfected cells were higher than in the other two groups (control and miR‑1284 inhibitor). In conclusion, the results suggest that miR‑1284 affects cell proliferation and apoptosis of lung cancer cells, indicating that miR‑1284 may have a key role in lung tumorigenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.