ArticleMolecular medicine reports2017
Endothelial growth medium suppresses apoptosis of mesenchymal stem cells in vitro via decrease of miR‑29a.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Optimization of Microenvironments Inducing Differentiation of Tonsil-Derived Mesenchymal Stem Cells into Endothelial Cell-Like Cells.Tissue engineering and regenerative medicine · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The administration of mesenchymal stem cells (MSCs) in cases of cardiac ischemia/reperfusion injury (IRI) has been associated with a significant reduction of myocardial cell death and an effective improvement in cardiac function. However, one major limiting factor in MSCs transplantation therapy is the low survival rate of the transplanted cells. The present study aimed to demonstrate that human amnion‑derived mesenchymal stem cells (hAMSCs) cultured with endothelial growth medium (EGM‑2) exhibited reduced apoptosis when exposed to serum‑free and hypoxic conditions; and that the expression of microRNA (miR)‑29a decreased significantly. Furthermore, miR‑29a knockdown resulted in decreased apoptosis of hAMSCs and increased myeloid cell leukemia (MCL)‑1 at the mRNA and protein levels. These results suggested that EGM‑2 promoted survival of hAMSCs partly through the regulation of miR‑29a and MCL‑1 expression levels. These findings may provide a novel understanding of a potential effective therapeutic strategy for cardiac IRI.
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