ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Implications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of repetitive transcranial magnetic stimulation in children and young people with psychiatric disorders: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping.Clinical psychology review · 2022Pooled it
- Infraslow Closed-Loop Brain Training for Anxiety and Depression (ISAD): A pilot randomised, sham-controlled trial in adult females with internalizing disorders.Cognitive, affective & behavioral neuroscience · 2025Trial
- Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?Development and psychopathology · 2018Trial
- Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts.Journal of psychopathology and clinical science · 2026Article
- Transdiagnostic MRI-derived Features of Psychopathology Following Traumatic Brain Injury: A Systematic Review.Neuropsychology review · 2026Review
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- From facing fears to experimental frontiers: immersive cinematic virtual reality environments as a catalyst for innovation in behavioral neuroscience.Frontiers in psychiatry · 2026Article
- Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study.The American journal of psychiatry · 2025Article
- A longitudinal investigation of the relationship between dimensional psychopathology, gray matter structure, and dementia status in older adulthood.Psychological medicine · 2025Article
- Group-to-individual generalizability and individual-level inferences in cognitive neuroscience.Neuroscience and biobehavioral reviews · 2025Review
- Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology.Psychological medicine · 2024Article
- Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra.Research square · 2024Article
- Integrating the BIDS Neuroimaging Data Format and Workflow Optimization for Large-Scale Medical Image Analysis.Journal of digital imaging · 2022Article
- Article
- Subjective assessments of research domain criteria constructs in addiction and compulsive disorders: a scoping review protocol.BMJ open · 2022Article
- The relationship between brain structure and general psychopathology in preadolescents.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
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Abstract
Research into the neurobiological substrates of psychopathology has been impeded by heterogeneity within diagnostic categories, comorbidity among mental disorders, and the presence of symptoms that transcend diagnostic categories. Solutions to these issues increasingly focus neurobiological research on isolated or narrow groupings of symptoms or functional constructs rather than categorical diagnoses. Here we argue for a more integrative approach that also incorporates the broad hierarchical structure of psychopathological symptoms and their etiological mechanisms. This approach places clinical neuroscience research in the context of a hierarchy of empirically defined factors of symptoms such as internalizing disorders, externalizing disorders, and the general factor of psychopathology. Application of this hierarchical approach has the potential to reveal neural substrates that nonspecifically contribute to multiple forms of psychopathology and their comorbidity, and in doing so, facilitate the study of mechanisms that are specific to single dimensions and subsets of symptoms. Neurobiological research on the hierarchy of dimensions of psychopathology is only just beginning to emerge, but has the potential to radically alter our understanding of the neurobiology of abnormal behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.