Evidence map›Paper›PMID 28713770›Full record

ArticleFrontiers in oncology2017

Prognostic Impact of AJCC/UICC 8th Edition New Staging Rules in Oropharyngeal Squamous Cell Carcinoma.

Nora Würdemann, Steffen Wagner, Shachi Jenny Sharma, Elena-Sophie Prigge, Miriam Reuschenbach, Stefan Gattenlöhner, Jens Peter Klussmann, Claus Wittekindt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  4. Pre-CCRT 18-fluorodeoxyglucose PET-CT improves survival in patients with advanced stages p16-negative oropharyngeal squamous cell carcinoma via accurate radiation treatment planning.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nora WürdemannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen, Giessen, Germany.
Steffen WagnerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen, Giessen, Germany.
Shachi Jenny SharmaDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen, Giessen, Germany.
Elena-Sophie PriggeDepartment of Applied Tumor Biology, University of Heidelberg, Heidelberg, Germany.
Miriam ReuschenbachDepartment of Applied Tumor Biology, University of Heidelberg, Heidelberg, Germany.
Stefan GattenlöhnerInstitute of Pathology, University of Giessen, Giessen, Germany.
Jens Peter KlussmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen, Giessen, Germany.
Claus WittekindtDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen, Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this study was to test whether the 8th edition of the AJCC/UICC TNM staging system (UICC) precisely differentiates between stages and reflects disease outcome in human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). PATIENTS AND

methodsOPSCC patients that were diagnosed between 2000 and 2016 were included in this analysis and HPV status was determined by combined DNA and p16 testing. Stratification was done according to 7th and 8th UICC staging rules. Incidence trends of HPV-associated tumorigenesis, 5-year overall survival (OS) according to tumor stages as well as the influence of therapy and prognostic factors toward the outcome were calculated using Kaplan-Meier method and Cox proportional-hazards model.

resultsA significant increase [2000; DISCUSSION: While the 7th edition of UICC shows invalid discrimination between stages, the 8th edition is more suitable for HPV-associated carcinoma. Due to lack of differentiation between stages II and III further adaption is essential.

Indexed as

head and neck cancerhuman papilloma virusoropharyngeal cancerprognosissurgeryUICC 7UICC 8

Identifiers

PMID28713770
PMCPMC5491554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.