ArticleFrontiers in genetics2017
Computational Analysis of Lifespan Experiment Reproducibility.
Article in Frontiers in genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation.Aging cell · 2026Article
- Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation.bioRxiv : the preprint server for biology · 2026Article
- Review
- Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans.GeroScience · 2024Article
- A clustering-based survival comparison procedure designed to study the Caenorhabditis elegans model.Scientific reports · 2024Article
- Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology.bioRxiv : the preprint server for biology · 2024Article
- Rapid measurement of ageing by automated monitoring of movement of C. elegans populations.GeroScience · 2024Article
- Proteostasis is differentially modulated by inhibition of translation initiation or elongation.eLife · 2023Article
- Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms ineLife · 2023Article
- A robotic system for automated genetic manipulation and analysis ofPNAS nexus · 2023Article
- Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance ineLife · 2022Article
- The Replica Set Method is a Robust, Accurate, and High-Throughput Approach for Assessing and Comparing Lifespan inFrontiers in aging · 2022Article
- Modeling aging and its impact on cellular function and organismal behavior.Experimental gerontology · 2021Review
- Article
- ApplyingFrontiers in aging · 2021Article
- A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR.PLoS genetics · 2020Article
- Article
- Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.GeroScience · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Independent reproducibility is essential to the generation of scientific knowledge. Optimizing experimental protocols to ensure reproducibility is an important aspect of scientific work. Genetic or pharmacological lifespan extensions are generally small compared to the inherent variability in mean lifespan even in isogenic populations housed under identical conditions. This variability makes reproducible detection of small but real effects experimentally challenging. In this study, we aimed to determine the reproducibility of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.