ReviewFrontiers in immunology2017
The Toxicological Mechanisms of Environmental Soot (Black Carbon) and Carbon Black: Focus on Oxidative Stress and Inflammatory Pathways.
Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 369 citations in OpenAlex.
- Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies.International journal of environmental research and public health · 2019Pooled it
- A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter.Environment international · 2019Pooled it
- Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.Environmental health perspectives · 2019Pooled it
- Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study.Environment international · 2021Trial
- Is black carbon associated with cardiovascular and cancer mortality? Evidence from the Malmö Diet and Cancer Cohort.Global health action · 2026Article
- Article
- Association between exposure to indoor PMBMC public health · 2026Article
- Black carbon as a compound agricultural stressor: impacts on plant physiology, crop productivity, and agricultural sustainability.Plant cell reports · 2026Review
- Industrial Hydrocarbons Exposure Deteriorates Sperm Integrity and Reproductive Function.Journal of biochemical and molecular toxicology · 2026Article
- Association between PMBMC cardiovascular disorders · 2026Article
- Multi-model analysis of the combined toxic effects of ultrafine carbon black and amisulbrom on A549 Cells.Scientific reports · 2026Article
- Associations of PMBMC public health · 2026Article
- Prenatal exposure to air pollution and the development of autism spectrum disorder from birth to adolescence: A nationwide Danish cohort study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- A comprehensive examination of the impact of environmental pollution on lung cancer: A review.Journal of advanced research · 2026Review
- PMEco-Environment & Health · 2026Article
- Risk of PMiScience · 2026Article
- Differential association between ambient PMiScience · 2026Article
- Deposition of Occupational Aerosol Particles in a Three-Dimensional Adult Nasal Cavity Model: An Experimental Study.Bioengineering (Basel, Switzerland) · 2026Article
- Long-term exposure to fine particulate matter constituents and incident stroke risk among middle-aged and older adults in China: a cohort study.Frontiers in public health · 2026Article
- Long-term exposure to fine particulate matter and its constituents is related to self-reported visual impairment among middle-aged and older adults: a longitudinal study in China.BMC public health · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The environmental soot and carbon blacks (CBs) cause many diseases in humans, but their underlying mechanisms of toxicity are still poorly understood. Both are formed after the incomplete combustion of hydrocarbons but differ in their constituents and percent carbon contents. For the first time, "Sir Percival Pott" described soot as a carcinogen, which was subsequently confirmed by many others. The existing data suggest three main types of diseases due to soot and CB exposures: cancer, respiratory diseases, and cardiovascular dysfunctions. Experimental models revealed the involvement of oxidative stress, DNA methylation, formation of DNA adducts, and Aryl hydrocarbon receptor activation as the key mechanisms of soot- and CB-induced cancers. Metals including Si, Fe, Mn, Ti, and Co in soot also contribute in the reactive oxygen species (ROS)-mediated DNA damage. Mechanistically, ROS-induced DNA damage is further enhanced by eosinophils and neutrophils
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.