Evidence map›Paper›PMID 28713337›Full record

ArticleFrontiers in microbiology2017

The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of

Brant R Johnson, Sarah O'Flaherty, Yong Jun Goh, Ian Carroll, Rodolphe Barrangou, Todd R Klaenhammer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Functional role of surface layer proteins ofBioscience of microbiota, food and health · 2021
    Article
  8. Review
  9. Review
  10. Article
  11. Development of an Antigen Delivery Platform UsingFrontiers in microbiology · 2020
    Article
  12. Article
  13. ProbioticOncotarget · 2019
    Article
  14. An Acid Up-Regulated Surface Protein ofInternational journal of molecular sciences · 2019
    Article
  15. Review
  16. Review
  17. Article
  18. Engineering Components of theFrontiers in microbiology · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brant R JohnsonGraduate Program in Microbiology, College of Agriculture and Life Sciences, North Carolina State University, RaleighNC, United States.
Sarah O'FlahertyDepartment of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, RaleighNC, United States.
Yong Jun GohDepartment of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, RaleighNC, United States.
Ian CarrollDepartment of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel HillChapel Hill, NC, United States.
Rodolphe BarrangouGraduate Program in Microbiology, College of Agriculture and Life Sciences, North Carolina State University, RaleighNC, United States.
Todd R KlaenhammerGraduate Program in Microbiology, College of Agriculture and Life Sciences, North Carolina State University, RaleighNC, United States.
North Carolina State University · USUniversity of North Carolina at Chapel Hill · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
NIDDK NIH HHS P30 DK034987
6 · The paper itself

Abstract

Health-promoting aspects attributed to probiotic microorganisms, including adhesion to intestinal epithelia and modulation of the host mucosal immune system, are mediated by proteins found on the bacterial cell surface. Notably, certain probiotic and commensal bacteria contain a surface (S-) layer as the outermost stratum of the cell wall. S-layers are non-covalently bound semi-porous, crystalline arrays of self-assembling, proteinaceous subunits called S-layer proteins (SLPs). Recent evidence has shown that multiple proteins are non-covalently co-localized within the S-layer, designated S-layer associated proteins (SLAPs). In

Indexed as

fibronectinintestinal barrier integrityLactobacillusmucinprobioticserine proteaseS-layerS-layer associated proteins

Identifiers

PMID28713337
PMCPMC5491966
OpenAlexW2730159692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.