Evidence map›Paper›PMID 28713217›Full record

Observational studyCanadian respiratory journal2017

The Burden of Illness Related to Chronic Obstructive Pulmonary Disease Exacerbations in Québec, Canada.

Tam Dang-Tan, Shiyuan Zhang, Ruben V Tavares, Melissa Stutz, Afisi S Ismaila, Julie Vaillancourt, Diane Corriveau, Richard H Stanford, Xiwu Lin, Gilbert A Nadeau and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Canadian respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tam Dang-TanGlaxoSmithKline, Research Triangle Park, Durham, NC, USA.
Shiyuan ZhangGlaxoSmithKline, Mississauga, ON, Canada.
Ruben V TavaresGlaxoSmithKline, Mississauga, ON, Canada.
Melissa StutzJSS Medical Research Inc., Saint Laurent, QC, Canada.
Afisi S IsmailaGlaxoSmithKline, Research Triangle Park, Durham, NC, USA.
Julie VaillancourtJSS Medical Research Inc., Saint Laurent, QC, Canada.
Diane CorriveauGlaxoSmithKline, Mississauga, ON, Canada.
Richard H StanfordGlaxoSmithKline, Research Triangle Park, Durham, NC, USA.
Xiwu LinGlaxoSmithKline, Collegeville, PA, USA.
Gilbert A NadeauGlaxoSmithKline, Mississauga, ON, Canada.
Alexander SimidchievGlaxoSmithKline, Mississauga, ON, Canada.
Daria ParsonsJSS Medical Research Inc., Saint Laurent, QC, Canada.
John S SampalisJSS Medical Research Inc., Saint Laurent, QC, Canada.ORCID 0000-0002-0075-369X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) prevalence in Canada has risen over time. COPD-related exacerbations contribute to the increased health care utilization (HCU) in this population. This study investigated the impact of exacerbations on COPD-related HCU.

methodsThis retrospective observational cohort study used patient data from the Québec provincial health insurance databases. Eligible patients with a new HCU claim with a diagnostic billing for COPD during 2001-2010 were followed until March 31, 2011. Exacerbation rates and time to first exacerbation were assessed. Unadjusted analyses and multivariable models compared the rate of HCU by exacerbation classification (any [moderate/severe], moderate, or severe).

resultsThe exacerbation event rate in patients with an exacerbation was 34.3 events/100 patient-years (22.7 for moderate exacerbations and 11.6 for severe exacerbations). Median time to first exacerbation of any classification was 37 months. In unadjusted analyses, COPD-related HCU significantly increased with exacerbation severity. In the multivariable, HCU rates were significantly higher after exacerbation versus before exacerbation (

conclusionsExacerbations were associated with increased HCU, which was more pronounced for patients with severe exacerbations. Interventions to reduce the risk of exacerbations in patients with COPD may reduce disease burden.

Indexed as

AgedAged, 80 and overCohort StudiesDisease ProgressionEmergency Service, HospitalFemaleGeneral PractitionersHealth ServicesHospitalizationHumansMaleMiddle AgedMultivariate AnalysisPulmonary Disease, Chronic ObstructivePulmonologistsQuebec

Identifiers

PMID28713217
PMCPMC5496115

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.