ArticleHearing research2017
Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta).
Article in Hearing research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06729632 (Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss), which is not on this map. Cited by 118 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
Who cites it
118 citing papers in PubMed, 3 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models.PloS one · 2024Pooled it
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment.HNO · 2019Guideline
- Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas.Hearing research · 2026Article
- Temporal integration in the subcortical auditory system and behavioral evidence of its dysfunction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model.bioRxiv : the preprint server for biology · 2026Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis.bioRxiv : the preprint server for biology · 2026Article
- Persistent impairment of spatial hearing and neural binaural interaction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Steady-State Auditory Evoked Potentials in Workers Exposed to Occupational Noise.La Medicina del lavoro · 2025Article
- Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Prognostic significance of the QuickSIN score for future hearing threshold deterioration.Scientific reports · 2025Article
- The rise of cochlear gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms.Hearing research · 2025Article
- Noise-Induced Hearing Loss: Overview and Future Prospects for Research on Oxidative Stress.International journal of molecular sciences · 2025Review
- Developing a Calibration Method to Minimize Variability in Auditory Evoked Potentials.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Early control of cochlear viral load limits cochlear inflammation and prevents virus-induced sensorineural hearing loss.Journal of neuroinflammation · 2025Article
- Unravelling the Silence: Exploring Tinnitus Pathophysiology and the Promise of Traditional Chinese Medicine.International journal of general medicine · 2025Review
- The relationship and interdependence of auditory thresholds, proposed behavioural measures of hidden hearing loss, and physiological measures of auditory function.International journal of audiology · 2025Article
- Hierarchical differences in the encoding of amplitude modulation in the subcortical auditory system of awake nonhuman primates.Journal of neurophysiology · 2024Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs temporal processing and hearing-in-noise, a classic complaint of those with sensorineural hearing loss. Non-human primates appear to be less vulnerable to noise-induced hair-cell loss than rodents, but their susceptibility to synaptopathy has not been studied. Because establishing a non-human primate model may be important in the development of diagnostics and therapeutics, we examined cochlear innervation and the damaging effects of acoustic overexposure in young adult rhesus macaques. Anesthetized animals were exposed bilaterally to narrow-band noise centered at 2 kHz at various sound-pressure levels for 4 h. Cochlear function was assayed for up to 8 weeks following exposure via auditory brainstem responses (ABRs) and otoacoustic emissions (OAEs). A moderate loss of synaptic connections (mean of 12-27% in the basal half of the cochlea) followed temporary threshold shifts (TTS), despite minimal hair-cell loss. A dramatic loss of synapses (mean of 50-75% in the basal half of the cochlea) was seen on IHCs surviving noise exposures that produced permanent threshold shifts (PTS) and widespread hair-cell loss. Higher noise levels were required to produce PTS in macaques compared to rodents, suggesting that primates are less vulnerable to hair-cell loss. However, the phenomenon of noise-induced cochlear synaptopathy in primates is similar to that seen in rodents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.