Evidence map›Paper›PMID 28712455›Full record

ArticleCellular immunology2017

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age.

Susan L Swain, Olivia Kugler-Umana, Yi Kuang, Wenliang Zhang

Abstract read
In one paragraph

Article in Cellular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. IgDAging cell · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. B Cell Immunosenescence.Annual review of cell and developmental biology · 2020
    Review
  13. The ABCs of Granulomatous Lung Diseases: Age-associated B Cells.American journal of respiratory and critical care medicine · 2020
    Article
  14. Review
  15. Article
  16. Review
  17. Cytokine Response in SARS-CoV-2 Infection in the Elderly.Journal of inflammation research · 2020
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susan L SwainDepartment of Pathology, University of Massachusetts Medical School, United States. Electronic address: Susan.Swain@umassmed.edu.
Olivia Kugler-UmanaDepartment of Pathology, University of Massachusetts Medical School, United States.
Yi KuangDepartment of Pathology, University of Massachusetts Medical School, United States.
Wenliang ZhangDepartment of Pathology, University of Massachusetts Medical School, United States.

Funding

MOLECULAR BIOLOGY COREP01AG021600 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAYNES, LAURA · 2003 to 2016
$24.4M
T cell memory to TB in the lungP01AI046530 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 1999 to 2013
$22.2M
TRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5M
Impact of aging on naive CD4 T cell functionR37AG025805 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2005 to 2014
$3.9M
Enhancing the success of underrepresented students in the biomedical sciencesR25GM113686 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAPANE, KATE L, LEWIS, BRIAN C · 2015 to 2019
$1.7M
Protective function of virus-induced age-associated B cellsR21AI128606 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2018 to 2019
$461k
VACCINE STRATEGIES TO CIRCUMVENT AGE-ASSOCIATED IMMUNE DEFECTSR21AG058758 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2018 to 2019
$461k
NIAID NIH HHS P01 AI046530NIAID NIH HHS R21 AI128606NIAID NIH HHS T32 AI007349NIA NIH HHS P01 AG021600NIA NIH HHS R37 AG025805NIGMS NIH HHS R25 GM113686
6 · The paper itself

Abstract

In aged mice, conventional naive B cells decrease and a new population of age-associated B cells (ABC)

Indexed as

AgingAnimalsAntibodies, ViralB-Lymphocyte SubsetsCD4 Lymphocyte CountCD4-Positive T-LymphocytesHost-Pathogen InteractionsInfluenza A virusMice, Inbred BALB CMice, KnockoutModels, ImmunologicalOrthomyxoviridae InfectionsPlasma CellsT-Lymphocytes, Helper-InducerAntibodies, ViralAgingAntibody productionAntiviral responseB cell subsetsImmune responseInfluenza virusPathogen recognitionT-independent response

Identifiers

PMID28712455
PMCPMC5732074

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.