Observational studyClinical cardiology2017
Frailty is an independent prognostic marker in elderly patients with myocardial infarction.
Observational study in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.Wiener klinische Wochenschrift · 2020Pooled it
- Prognostic value of frailty in elderly patients with acute coronary syndrome: a systematic review and meta-analysis.BMC geriatrics · 2019Pooled it
- Frailty scale with the best prediction of mortality in individuals diagnosed with acute coronary syndrome: systematic review and meta-analysis.Journal of geriatric cardiology : JGC · 2026Article
- The effects of invasive treatment on patients with frailty and non-ST-segment elevation myocardial infarction.Scientific reports · 2025Article
- Prevalence of frailty and associated factors in Shanghai older community-dwelling adults: a cross-sectional study.BMJ open · 2025Article
- Frailty in older adults: A systematic review of risk factors and early intervention pathways.Intractable & rare diseases research · 2025Review
- Article
- Development and validation of machine learning-derived frailty index in predicting outcomes of patients undergoing percutaneous coronary intervention.International journal of cardiology. Heart & vasculature · 2024Article
- A Narrative Review of the Utilisation of the SHARE Frailty Instruments (SHARE-FI and SHARE-FI75+) in the Literature.Journal of frailty, sarcopenia and falls · 2023Review
- Frailty index and risk of cardiovascular diseases: a mendelian randomization study.Annals of translational medicine · 2022Article
- "I feel I have been taken seriously" Women's experience of greater trochanteric pain syndrome treatment-A nested qualitative study.PloS one · 2022Article
- Prevalence and determinants of frailty in older adult patients with chronic coronary syndrome: a cross-sectional study.BMC geriatrics · 2021Article
- Frailty Scores and Their Utility in Older Patients with Cardiovascular Disease.Interventional cardiology (London, England) · 2021Review
- Frailty and coronary plaque characteristics on optical coherence tomography.Heart and vessels · 2020Article
- Association of frailty with all-cause mortality and bleeding among elderly patients with acute myocardial infarction: a systematic review and meta-analysis.Journal of geriatric cardiology : JGC · 2020Article
- Impact of Different Geriatric Conditions on Choice of Therapy and In-Hospital Outcomes in Elderly Patients with Acute Coronary Syndrome.Clinical interventions in aging · 2020Article
- Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction: The SILVER-AMI Study.Circulation. Cardiovascular quality and outcomes · 2019Observational
- Impact of the clinical frailty scale on mid-term mortality in patients with ST-elevated myocardial infarction.International journal of cardiology. Heart & vasculature · 2019Article
- Frailty in Older Patients with Acute Coronary Syndrome in Vietnam.Clinical interventions in aging · 2019Article
- Risk stratification by means of biological age-related factors better predicts cancer-specific survival than chronological age in patients with upper tract urothelial carcinoma: a multi-institutional database study.Therapeutic advances in urology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute coronary syndrome (ACS) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents a better reflection of biological age. HYPOTHESIS: This study aims to determine the prevalence of frailty and its influence on patients age ≥75 years with ACS.
methodsPatients age ≥75 years admitted due to type 1 myocardial infarction were included in 2 tertiary hospitals, and clinical data were collected prospectively. Frailty was defined at admission using the previously validated Survey of Health Ageing and Retirement in Europe Frailty Index (SHARE-FI) tool. The primary endpoint was the combination of death or nonfatal myocardial reinfarction during a follow-up of 6 months. Major bleeding (hemoglobin decrease ≥3 g/dL or transfusion needed) and readmission rates were also explored.
resultsA total of 234 consecutive patients were included. Frail patients (40.2%) had a higher-risk profile, based on higher age and comorbidities. On multivariate analysis, frailty was an independent predictor of the combination of death or nonfatal myocardial reinfarction (adjusted hazard ratio [aHR]: 2.54, 95% confidence interval [CI]: 1.12-5.79), an independent predictor of the combination of death, nonfatal myocardial reinfarction, or major bleeding (aHR: 2.14, 95% CI: 1.13-4.04), and an independent predictor of readmission (aHR: 1.80, 95% CI: 1.00-3.22).
conclusionsFrailty phenotype at admission is common among elderly patients with ACS and is an independent predictor for severe adverse events. It should be considered in future risk-stratification models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.