Evidence map›Paper›PMID 28712090›Full record

Trial reportEuropean archives of psychiatry and clinical neuroscience2019

Does prior traumatization affect the treatment outcome of CBT for panic disorder? The potential role of the MAOA gene and depression symptoms.

Sebastian Trautmann, Jan Richter, Markus Muehlhan, Michael Höfler, Hans-Ulrich Wittchen, Katharina Domschke, Andreas Ströhle, Alfons O Hamm, Heike Weber, Tilo Kircher and 6 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of psychiatry and clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 1 country.

Sebastian TrautmannInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany. Sebastian.Trautmann1@tu-dresden.de.ORCID http://orcid.org/0000-0002-8976-3244
Jan RichterDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
Markus MuehlhanInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany.
Michael HöflerInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany.
Hans-Ulrich WittchenInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany.
Katharina DomschkeDepartment of Psychiatry, Psychosomatics, and Psychotherapy, University of Würzburg, Würzburg, Germany.
Andreas StröhleDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Alfons O HammDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
Heike WeberDepartment of Psychiatry, Psychosomatics, and Psychotherapy, University of Würzburg, Würzburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Volker AroltDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Alexander L GerlachDepartment of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.
Georg W AlpersPsychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Thomas FydrichInstitute of Psychology, Humboldt-University, Berlin, Germany.
Thomas LangChristoph-Dornier-Foundation for Clinical Psychology, Bremen, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University Frankfurt, Frankfurt, Germany.
Technische Universität Dresden · DEGoethe University Frankfurt · DEUniversität Greifswald · DECharité - Universitätsmedizin Berlin · DEDornier Flugzeugwerke (Germany) · DEHumboldt-Universität zu Berlin · DEMSH Medical School Hamburg – University of Applied Sciences and Medical University · DEPhilipps University of Marburg · DEUniversity of Cologne · DEUniversity of Freiburg · DEUniversity of Mannheim · DEUniversity of Münster · DE

Funding

German Federal Ministry of Education and Research 01GV0615
6 · The paper itself

Abstract

Although cognitive behavioral therapy (CBT) is highly effective in the treatment of anxiety disorders, many patients still do not benefit. This study investigates whether a history of traumatic event experience is negatively associated with outcomes of CBT for panic disorder. The moderating role of the monoamine oxidase A (MAOA) gene and depression symptoms as well as the association between trauma history and fear reactivity as a potential mechanism are further analyzed. We conducted a post-hoc analysis of 172 male and 60 female patients with panic disorder treated with CBT in a multi-center study. Treatment outcome was assessed at post-treatment using self-report and clinician rating scales. Fear reactivity before treatment was assessed via heart rate and self-reported anxiety during a behavioral avoidance test. Among females, we did not find any differences in treatment response between traumatized and non-traumatized individuals or any two-way interaction trauma history × MAOA genotype. There was a significant three-way interaction trauma history × MAOA genotype × depression symptoms on all treatment outcomes indicating that in traumatized female patients carrying the low-activity allele, treatment effect sizes decreased with increasing depression symptoms at baseline. No such effects were observed for males. In conclusion, we found no evidence for a differential treatment response in traumatized and non-traumatized individuals. There is preliminary evidence for poorer treatment outcomes in a subgroup of female traumatized individuals carrying the low-active variant of the MAOA gene. These patients also report more symptoms of depression symptomatology and exhibit a dampened fear response before treatment which warrants further investigation.

Indexed as

Cognitive Behavioral TherapyOutcome Assessment, Health CareAdultComorbidityDepressionFearFemaleHumansMaleMonoamine OxidasePanic DisorderPsychological TraumaSex FactorsMonoamine Oxidasemonoamine oxidase A, humanCBTDepressionFear reactivityMAOAPanic disorderTrauma

Identifiers

PMID28712090
OpenAlexW2734609620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.