ArticleEuropean archives of psychiatry and clinical neuroscience2019
Increased recruitment of cognitive control in the presence of traumatic stimuli in complex PTSD.
Article in European archives of psychiatry and clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- PTSD subtypes and their underlying neural biomarkers: a systematic review.Psychological medicine · 2025Pooled it
- Pooled it
- Emotional Memory in Post-traumatic Stress Disorder: A Systematic PRISMA Review of Controlled Studies.Frontiers in psychology · 2019Pooled it
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Distinct and shared neurobiological patterns in PTSD and CPTSD: evidence from resting-state fMRI.BMC psychiatry · 2026Article
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives.Frontiers in psychiatry · 2026Article
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Altered functional connectivity between cortical networks associated with inhibitory control in trauma-exposed females.Psychiatry research. Neuroimaging · 2023Article
- The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder.Scientific reports · 2023Article
- Differentiated processing of emotional cues in adolescents and young adults with ICD-11 PTSD and complex PTSD after child abuse.Brain and behavior · 2023Article
- Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction.Development and psychopathology · 2022Article
- Emerging experience with selected new categories in the ICD-11: complex PTSD, prolonged grief disorder, gaming disorder, and compulsive sexual behaviour disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Complex PTSD and borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2021Review
- Maladaptive Alterations of Defensive Response Following Developmental Complex Stress in Rats.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Opponent Effects of Hyperarousal and Re-experiencing on Affective Habituation in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates.Journal of affective disorders · 2019Article
- A research programme to evaluate DBT-PTSD, a modular treatment approach for Complex PTSD after childhood abuse.Borderline personality disorder and emotion dysregulation · 2019Article
- Association Between Initial Age of Exposure to Childhood Abuse and Cognitive Control: Preliminary Evidence.Journal of traumatic stress · 2018Article
- Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan.Frontiers in psychiatry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
A neurocircuitry model of post-traumatic stress disorder (PTSD) suggests increased amygdala responses to emotional stimuli, coupled with hypoactivation of prefrontal regions associated with cognitive control. However, results are heterogenous across different subsamples of PTSD as well as different paradigms. We investigated cognitive control in a classic and emotional Stroop task in 28 female patients with complex PTSD (cPTSD), 28 female trauma-exposed healthy controls (TCs) and 28 female non-trauma-exposed healthy controls (HCs) using functional neuroimaging. Afterwards, we assessed memory function in a spontaneous free recall and recognition task. Patients with cPTSD displayed significantly greater Stroop interference with trauma-related words (as reflected in slower reaction times and increased errors) compared to the other conditions and compared to the TC and HC groups. Moreover, patients with cPTSD showed increased activation in the context of trauma-related words in brain regions associated with cognitive control (dlPFC, vmPFC, dACC) compared to both control groups, and a trend for increased activation in the insula compared to the HC group. Increased recruitment of regions contributing to cognitive control in patients with cPTSD, together with a lack of amygdala response may point to efforts to compensate for emotional distraction caused by the trauma-related words.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.