ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2018
Good clinical results but moderate osseointegration and defect filling of a cell-free multi-layered nano-composite scaffold for treatment of osteochondral lesions of the knee.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Subchondral bone: An emerging target for the treatment of articular surface lesions of the knee.Journal of experimental orthopaedics · 2024Review
- The MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 2.0 Knee Score and Atlas.Cartilage · 2021Article
- Multi-layer cell-free scaffolds for osteochondral defects of the knee: a systematic review and meta-analysis of clinical evidence.Journal of experimental orthopaedics · 2021Review
- Accurate Reporting of Concomitant Procedures Is Highly Variable in Studies Investigating Knee Cartilage Restoration.Cartilage · 2021Article
- Autologous chondrocytes versus filtered bone marrow mesenchymal stem/stromal cells for knee cartilage repair-a prospective study.International orthopaedics · 2021Article
- Studies of Articular Cartilage Repair from 2009 to 2018: A Bibliometric Analysis of Articles.Orthopaedic surgery · 2021Review
- Influence of the Mechanical Environment on the Regeneration of Osteochondral Defects.Frontiers in bioengineering and biotechnology · 2021Review
- MaioRegen Osteochondral Substitute for the Treatment of Knee Defects: A Systematic Review of the Literature.Journal of clinical medicine · 2019Review
- Agili-C implant promotes the regenerative capacity of articular cartilage defects in an ex vivo model.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Neither significant osteoarthritic changes nor deteriorating subjective outcomes occur after hybrid fixation of osteochondritis dissecans in the young adult.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Ectopic chondrogenesis of nude mouse induced by nano gene delivery enhanced tissue engineering technology.International journal of nanomedicine · 2019Article
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Authors and funding
5 authors.
Funding
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Abstract
purposeThe aim of this retrospective study was to evaluate the clinical and radiological results of a nano-composite multi-layered three-dimensional biomaterial scaffold for treatment of osteochondral lesions (OCL) of the knee. It was a particular radiological interest to analyse the osseointegration, filling of the defects and the bone tracer uptake (BTU), and it was hypothesised that this scaffold, which was created to mimic the entire osteo-cartilaginous unit, is integrated within the bone 12 months postoperatively and comes along with improved patients symptoms and function.
methodsFourteen patients (male:female = 11:3, mean age ± SD 33.1 ± 10.7 years) treated for OCL (size 1.0-3.5 cm
resultsA significant improvement in Lysholm knee score (p < 0.001) and slight deterioration in Tegner score were found (p < 0.01). A complete filling of the defect was shown in 14%, a partial filling in 14% and only minor filling was seen in 72%. A significant correlation (p < 0.001) was found between location of osteochondral lesions and increased BTU. At the lesion sites pre- and postoperative BTU was markedly increased and did not show any decrease at 12-month follow-up. Median Tegner and mean Lysholm scores did not correlate with BTU at any time.
conclusionsTreatment of OCL in the knee joint with a nano-composite multi-layered three-dimensional biomaterial scaffold resulted in a significant clinical improvement at 1-year follow-up. However, osseointegration was still ongoing at 12-month follow-up. LEVEL OF EVIDENCE: Case series, Level IV.
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