Evidence map›Paper›PMID 28711972›Full record

Trial reportDiabetologia2017

The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT/EDIC study.

Ionut Bebu, Barbara H Braffett, Rodica Pop-Busui, Trevor J Orchard, David M Nathan, John M Lachin, DCCT/EDIC Research Group

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00360815 nacompletednot on this map

Diabetes Control and Complications Trial (DCCT)

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran1983 to 1993Enrolled1,441ConditionsType 1 Diabetes MellitusArmsInsulin
NCT00360893 active not recruitingnot on this map

Epidemiology of Diabetes Interventions and Complications (EDIC)

TypeobservationalSponsorGeorge Washington UniversityRan1994 to 2027Enrolled1,441ConditionsType 1 Diabetes Mellitus
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 83 citations in OpenAlex.

  1. Trial
  2. Trial
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  5. Trial
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Precision Medicine in Type 1 Diabetes.Journal of the Indian Institute of Science · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. The JUBILE cohort: Quality of life after more than 40 years with type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ionut BebuThe Biostatistics Center, The George Washington University, 6110 Executive Boulevard, Rockville, MD, 20852, USA. ibebu@bsc.gwu.edu.
Barbara H BraffettThe Biostatistics Center, The George Washington University, 6110 Executive Boulevard, Rockville, MD, 20852, USA.
Rodica Pop-BusuiDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Trevor J OrchardGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
David M NathanMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
John M LachinThe Biostatistics Center, The George Washington University, 6110 Executive Boulevard, Rockville, MD, 20852, USA.
DCCT/EDIC Research Group
George Washington University · USHarvard University · USUniversity of Michigan–Ann Arbor · USUniversity of Pittsburgh · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

aims/hypothesisChronic hyperglycaemia, as measured by HbA

methodsThe DCCT and its observational follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC), followed 1441 participants for a mean of 27 years, with periodic measurement of HbA

resultsThe association of HbA CONCLUSIONS/

interpretationAs participants age, the predictive association of mean HbA

trial registrationClinicalTrials.gov NCT00360893 and NCT00360815.

Indexed as

Blood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHumansHyperglycemiaHypoglycemic AgentsMaleModels, TheoreticalRisk FactorsBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsArea under the curveCardiovascular diseaseMediation proportionType 1 diabetes

Identifiers

PMID28711972
PMCPMC5660661
OpenAlexW2734911247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.