Evidence map›Paper›PMID 28711633›Full record

ArticleHeart rhythm2017

Novel measure of autonomic remodeling associated with sudden cardiac arrest in diabetes.

Yang Yang, Aapo L Aro, Sandeep G Nair, Reshmy Jayaraman, Kyndaron Reinier, Carmen Rusinaru, Audrey Uy-Evanado, Hirad Yarmohammadi, Jonathan Jui, Sumeet S Chugh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yang YangHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Aapo L AroHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California; Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Sandeep G NairHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Reshmy JayaramanHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Kyndaron ReinierHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Carmen RusinaruHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Audrey Uy-EvanadoHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Hirad YarmohammadiHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Jonathan JuiOregon Health and Science University, Portland, Oregon.
Sumeet S ChughHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: sumeet.chugh@cshs.org.
Cedars-Sinai Medical Center · USOregon Health & Science University · US

Funding

Sudden Cardiac Death with Preserved Left Ventricular Ejection FractionR01HL126938 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHUGH, SUMEET S. · 2016 to 2019
$2.6M
Sudden Cardiac Death in Middle AgeR01HL122492 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHUGH, SUMEET S. · 2015 to 2018
$2.2M
NHLBI NIH HHS R01 HL122492NHLBI NIH HHS R01 HL126938
6 · The paper itself

Abstract

backgroundDiabetes is independently associated with an increased risk of sudden cardiac arrest (SCA), with a need to identify novel methods for risk stratification. Diabetic patients can develop autonomic dysfunction that has been associated with an increased risk of ventricular arrhythmogenesis and manifests as reduced heart rate variability (HRV). However, previously published studies have not accounted for resting heart rate (HR), important from both pathophysiological and prognosticating standpoints.

objectiveWe sought to evaluate autonomic remodeling of the sinus node response in SCA and diabetes while accounting for HR.

methodsWe performed a case-control study in SCA cases (age 35-59 years; 2002-2014) from the ongoing Oregon Sudden Unexpected Death Study (catchment population ∼1 million), and archived 12-lead electrocardiograms recorded prior to the SCA event were compared with those of geographic controls. Short-term HRV was calculated from digitized 10-second electrocardiograms by using established methods. We analyzed 313 subjects (mean age 52.0 ± 5.5 years; 216 men, 69.0%) and compared 4 groups: 111 diabetic (49 cases, 62 controls) and 202 nondiabetic (80 cases, 122 controls) subjects.

resultsAnalysis of covariance showed an absence of the expected interaction between HRV and HR (HRV-HR) in diabetic patients with SCA (regression slope -0.008; 95% confidence interval -0.023 to 0.0071; P = .26). This finding, unique to this population of diabetic patients with SCA, was not detected using traditional HRV measures.

conclusionBy incorporating resting HR in this analysis, we observed that this population of diabetic patients with SCA had loss of the expected HRV-HR relationship. This potentially novel noninvasive risk measurement warrants further investigation, especially at the level of the individual patient.

Indexed as

Population SurveillanceRisk AssessmentAdultAutonomic Nervous SystemCase-Control StudiesDeath, Sudden, CardiacDiabetes MellitusElectrocardiographyFemaleHeart RateHumansIncidenceMaleMiddle AgedOregonProspective StudiesDiabetesElectrocardiogramHeart rate variabilityRisk stratificationSudden cardiac arrestSudden death

Identifiers

PMID28711633
PMCPMC5624843
OpenAlexW2735077451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.