ArticleGastroenterology2017
Analysis of Liver Offers to Pediatric Candidates on the Transplant Wait List.
Article in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Expanding the Donor Pool in Pediatric Transplantations: Successful Domino Liver Transplantation From the Youngest Reported Pediatric DCD Donor Using Normothermic Regional Perfusion in the United States.Pediatric transplantation · 2026Article
- A 10-year analysis of the united network for organ sharing registry: Insights from machine learning to prevent pediatric waitlist deaths.Journal of pediatric gastroenterology and nutrition · 2026Article
- Transplantation as disease modifying therapy in the era of gene therapy medicinal products - health policy considerations.Orphanet journal of rare diseases · 2026Review
- National registry on characteristics and outcomes of pediatric liver transplantation in a middle-income country.BMC pediatrics · 2026Article
- Comparison of short-term outcomes of open, laparoscopic, and robotic surgery for Kasai portoenterostomy in biliary atresia: a 10-year single center study.Frontiers in surgery · 2026Article
- Transfer of Aging: Implications for Pediatric Solid Organ Transplantation.Pediatric transplantation · 2025Review
- Variability in pediatric and neonatal organ offering, acceptance and utilization: a survey of Canadian pediatric transplant programs and organ donation organizations.Frontiers in transplantation · 2024Article
- Can non-directed living liver donation help improve access to grafts and correct socioeconomic disparities in pediatric liver transplantation?Pediatric transplantation · 2023Article
- Living Donor Versus Deceased Donor Pediatric Liver Transplantation: A Systematic Review and Meta-analysis.Transplantation direct · 2021Article
- Medium-term outcomes after laparoscopic revision of laparoscopic Kasai portoenterostomy in patients with biliary atresia.Orphanet journal of rare diseases · 2021Article
- Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates.Transplantation · 2020Article
- Hepatic expression of HGF/C-met and native liver survival in biliary atresia.Pediatric surgery international · 2020Article
- Split liver transplantation is utilized infrequently and concentrated at few transplant centers in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Short- and Long-Term Outcomes After Live-Donor Transplantation with Hyper-Reduced Liver Grafts in Low-Weight Pediatric Recipients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A learning health network for pediatric liver transplantation: Inaugural meeting report from the Starzl Network for Excellence in Pediatric Transplantation.Pediatric transplantation · 2019Article
- The Impact of Increased Allocation Priority for Children Awaiting Liver Transplant: A Liver Simulated Allocation Model (LSAM) Analysis.Journal of pediatric gastroenterology and nutrition · 2019Article
- Split Liver Transplantation and Pediatric Waitlist Mortality in the United States: Potential for Improvement.Transplantation · 2019Article
- Superior Outcomes and Reduced Wait Times in Pediatric Recipients of Living Donor Liver Transplantation.Transplantation direct · 2019Article
- Deceased Pediatric Donor Livers: How Current Policy Drives Allocation and Transplantation.Hepatology (Baltimore, Md.) · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
aimsApproximately 10% of children on the liver transplant wait-list in the United States die every year. We examined deceased donor liver offer acceptance patterns and their contribution to pediatric wait-list mortality.
methodsWe performed a retrospective cohort study of children on the US liver transplant wait-list from 2007 through 2014 using national transplant registry databases. We determined the frequency, patterns of acceptance, and donor and recipient characteristics associated with deceased donor liver organ offers for children who died or were delisted compared with those who underwent transplantation. Children who died or were delisted were classified by the number of donor liver offers (0 vs 1 or more), limiting analyses to offers of livers that were ultimately transplanted into pediatric recipients. The primary outcome was death or delisting on the wait-list.
resultsAmong 3852 pediatric liver transplant candidates, children who died or were delisted received a median 1 pediatric liver offer (inter-quartile range, 0-2) and waited a median 33 days before removal from the wait-list. Of 11,328 donor livers offered to children, 2533 (12%) were transplanted into children; 1179 of these (47%) were immediately accepted and 1354 (53%) were initially refused and eventually accepted for another child. Of 27,831 adults, 1667 (6.0%; median, 55 years) received livers from donors younger than 18 years (median, 15 years), most (97%) allocated locally or regionally. Of children who died or were delisted, 173 (55%) received an offer of 1 or more liver that was subsequently transplanted into another pediatric recipient, and 143 (45%) died or were delisted with no offers.
conclusionsAmong pediatric liver transplant candidates in the US, children who died or were delisted received a median 1 pediatric liver offer and waited a median of 33 days. Of livers transplanted into children, 47% were immediately accepted and 53% were initially refused and eventually accepted for another child. Of children who died or were delisted, 55% received an offer of 1 or more liver that was subsequently transplanted into another pediatric recipient, and 45% died or were delisted with no offers. Pediatric prioritization in the allocation and development of improved risk stratification systems is required to reduce wait-list mortality among children.
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