ArticleNeuroscience2017
Prolonged low-level noise-induced plasticity in the peripheral and central auditory system of rats.
Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Industrial noise: impacts on workers' health and performance below permissible limits.BMC public health · 2025Article
- Role of the Dorsal Cortex of the Inferior Colliculus in the Precedence Effect.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Functional MRI reveals subcortical auditory push-pull interactions requiring intercollicular integrity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Counseling Protocol for a Transitional Intervention for Debilitating Hyperacusis.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- High-frequency Noise-induced Hearing Loss Disrupts Functional Connectivity in Non-auditory Areas with Cognitive Disturbances.Neuroscience bulletin · 2021Article
- Occupational Noise: Auditory and Non-Auditory Consequences.International journal of environmental research and public health · 2020Review
- 2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose.Neurotoxicity research · 2020Article
- Blast-induced hearing loss suppresses hippocampal neurogenesis and disrupts long term spatial memory.Hearing research · 2020Article
- The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds.NeuroImage · 2020Article
- Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala.Neuroscience · 2019Article
- The rat animal model for noise-induced hearing loss.The Journal of the Acoustical Society of America · 2019Review
- Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.Experimental gerontology · 2019Article
- Long-term exposure to moderate noise induces neural plasticity in the infant rat primary auditory cortex.Animal cells and systems · 2019Article
- Prolonged low-level noise exposure reduces rat distortion product otoacoustic emissions above a critical level.Hearing research · 2018Article
- Auditory central gain compensates for changes in cochlear output after prolonged low-level noise exposure.Neuroscience letters · 2018Article
- Hidden cochlear impairments.Journal of otology · 2018Review
- Effect of Titrated Exposure to Non-Traumatic Noise on Unvoiced Speech Recognition in Human Listeners with Normal Audiological Profiles.Trends in hearingArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Prolonged low-level noise exposure alters loudness perception in humans, presumably by decreasing the gain of the central auditory system. Here we test the central gain hypothesis by measuring the acute and chronic physiologic changes at the level of the cochlea and inferior colliculus (IC) after a 75-dB SPL, 10-20-kHz noise exposure for 5weeks. The compound action potential (CAP) and summating potential (SP) were used to assess the functional status of the cochlea and 16 channel electrodes were used to measure the local field potentials (LFP) and multi-unit spike discharge rates (SDR) from the IC immediately after and one-week post-exposure. Measurements obtained immediately post-exposure demonstrated a significant reduction in supra-threshold CAP amplitudes. In contrast to the periphery, sound-evoked activity in the IC was enhanced in a frequency-dependent manner consistent with models of enhanced central gain. Surprisingly, one-week post-exposure supra-threshold responses from the cochlea had not only recovered, but were significantly larger than normal, and thresholds were significantly better than controls. Moreover, sound-evoked hyperactivity in the IC was sustained within the noise exposure frequency band but suppressed at higher frequencies. When response amplitudes representing the neural output of the cochlea and IC activity at one-week post exposure were compared with control animal responses, a central attenuation phenomenon becomes evident, which may play a key role in understanding why low-level noise can sometimes ameliorate tinnitus and hyperacusis percepts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.