Evidence map›Paper›PMID 28711621›Full record

ArticleNeuroscience2017

Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression.

Grazyna Rajkowska, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R Albert, Mireille Daigle, Jose J Miguel-Hidalgo, Mark C Austin, Randy D Blakely and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Elevated levels of serotonin 5-HTEuropean archives of psychiatry and clinical neuroscience · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Adult neuroplasticity: A new “cure” for major depression?Journal of psychiatry & neuroscience : JPN · 2019
    Article
  13. Review
  14. Frontiers in neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Grazyna RajkowskaDepartment of Psychiatry and Human Behavior, School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: grajkowska@umc.edu.
Gouri MahajanDepartment of Psychiatry and Human Behavior, School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: gmahajan@umc.edu.
Beata LegutkoDepartment of Psychiatry and Human Behavior, School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: beatalgtk0@gmail.com.
Lavanya ChallagundlaDepartment of Data Science, JD Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: lchallagundla@umc.edu.
Michael GriswoldDepartment of Data Science, JD Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: mgriswold@umc.edu.
Paul R AlbertOttawa Hospital Research Institute (Neuroscience) and UOttawa Brain and Mind Research Institute, Ottawa, ON K1H 8M5, Canada. Electronic address: palbert@uottawa.ca.
Mireille DaigleOttawa Hospital Research Institute (Neuroscience) and UOttawa Brain and Mind Research Institute, Ottawa, ON K1H 8M5, Canada. Electronic address: Mireille.Daigle@uOttawa.ca.
Jose J Miguel-HidalgoDepartment of Psychiatry and Human Behavior, School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. Electronic address: jmiguel-hidalgo@umc.edu.
Mark C AustinDepartment of Biological Sciences, Idaho State University, Pocatello, ID 83209, USA. Electronic address: austinm@isu.edu.
Randy D BlakelyDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: Randy.Blakely@Vanderbilt.edu.
David C SteffensDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA. Electronic address: STEFFENS@uchc.edu.
Craig A StockmeierDepartment of Psychiatry and Human Behavior, School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: cstockmeier@umc.edu.
University of Mississippi Medical Center · USuOttawa Brain and Mind Research InstituteIdaho State University · USUniversity of Connecticut · USVanderbilt University · US

Funding

Geriatric Depression: Risk Factors for Adverse OutcomesR01MH054846 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI STEFFENS, DAVID C. · 1995 to 2016
$10.1M
Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
CIHR 115098-1CIHR 123426-1NIGMS NIH HHS P30 GM103328NIMH NIH HHS R01 MH054846
6 · The paper itself

Abstract

Studies of major depressive disorder (MDD) in postmortem brain tissue report enhanced binding to inhibitory serotonin-1A autoreceptors in midbrain dorsal raphe and reductions in length of axons expressing the serotonin transporter (SERT) in dorsolateral prefrontal cortex. The length density of axons expressing SERT in the orbitofrontal cortex (OFC) was determined in 18 subjects with MDD and 17 age-matched control subjects. A monoclonal antibody was used to immunohistochemically label the SERT in fixed sections of OFC. The 3-dimensional length density of SERT-immunoreactive (ir) axons in layer VI of OFC was estimated. The age of subjects with MDD was negatively correlated with SERT axon length (r=-0.77, p<0.0005). The significant effect of age persisted when removing four depressed subjects with an antidepressant medication present at the time of death, or when removing nine depressed subjects that had a recent prescription for an antidepressant medication. Neither gender, tissue pH, postmortem interval, 5-HTTLPR genotype, time in fixative, nor death by suicide had a significant effect on axon length. The age-related decrease in SERT-ir axon length in MDD may reflect pathology of ascending axons passing through deep white matter hyperintensities. Greater length of axons expressing SERT in younger subjects with MDD may result in a significant deficit in serotonin availability in OFC.

Indexed as

AdultAgedAged, 80 and overAge FactorsAxonsFemaleHumansMajor Depressive DisorderMaleMiddle AgedPrefrontal CortexSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport Proteinsagemajor depressive disordermorphometryorbitofrontal cortexpostmortemserotonin transporter

Identifiers

PMID28711621
PMCPMC5567856
OpenAlexW2736205326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.