ArticleJournal of vascular surgery2017
Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation.
Article in Journal of vascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Experimental Evaluation of an Array Transducer for Ultrasound Thermal Strain Imaging: Phantom and In Vivo Studies.Ultrasound in medicine & biology · 2025Article
- Multi-parametric Photoacoustic Imaging Combined with Acoustic Radiation Force Impulse Imaging for Applications in Tissue Engineering.Annals of biomedical engineering · 2025Article
- Comparison of Filtering Methods for Calculating ARFI log(VoA) to Delineate Carotid Plaque Features, In Vivo.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025Article
- Comparing Focused-Tracked and Plane Wave-Tracked ARFI Log(VoA) In Silico and in Application to Human Carotid Atherosclerotic Plaque, Ex Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Novel ultrasound techniques in the identification of vulnerable plaques-an updated review of the literature.Frontiers in cardiovascular medicine · 2023Review
- Imaging of Single Transducer-Harmonic Motion Imaging-Derived Displacements at Several Oscillation Frequencies Simultaneously.IEEE transactions on medical imaging · 2022Article
- Advances in Noninvasive Carotid Wall Imaging with Ultrasound: A Narrative Review.Journal of clinical medicine · 2022Review
- Multimodality carotid plaque tissue characterization and classification in the artificial intelligence paradigm: a narrative review for stroke application.Annals of translational medicine · 2021Review
- Feasibility of Harmonic Motion Imaging Using a Single Transducer: In Vivo Imaging of Breast Cancer in a Mouse Model and Human Subjects.IEEE transactions on medical imaging · 2021Article
- Electronic Point Spread Function Rotation Using a Three-Row Transducer for ARFI-Based Elastic Anisotropy Assessment: In Silico and Experimental Demonstration.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Carotid Plaque Fibrous Cap Thickness Measurement by ARFI Variance of Acceleration: In Vivo Human Results.IEEE transactions on medical imaging · 2020Article
- Lagrangian carotid strain imaging indices normalized to blood pressure for vulnerable plaque.Journal of clinical ultrasound : JCU · 2019Article
- Delineation of Human Carotid Plaque Features In Vivo by Exploiting Displacement Variance.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Observational
- ARFI variance of acceleration (VoA) for noninvasive characterization of human carotid plaques in vivo.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2017Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveStroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation.
methodsCarotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy. The surgical specimens were histologically processed with sectioning matched to the ultrasound imaging plane. Three radiologists, blinded to histology, evaluated parametric images of ARFI-induced peak displacement to identify plaque features such as necrotic core (NC), intraplaque hemorrhage (IPH), collagen (COL), calcium (CAL), and fibrous cap (FC) thickness. Reader performance was measured against the histologic standard using receiver operating characteristic curve analysis, linear regression, Spearman correlation (ρ), and Bland-Altman analysis.
resultsARFI peak displacement was two-to-four-times larger in regions of NC and IPH relative to regions of COL or CAL. Readers detected soft plaque features (NC/IPH) with a median area under the curve of 0.887 (range, 0.867-0.924) and stiff plaque features (COL/CAL) with median area under the curve of 0.859 (range, 0.771-0.929). FC thickness measurements of two of the three readers correlated with histology (reader 1: R
conclusionsThis study suggests that ARFI is capable of distinguishing soft from stiff atherosclerotic plaque components and delineating FC thickness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.