Evidence map›Paper›PMID 28711335›Full record

ArticleInternational journal of cardiology2017

Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa.

Edith D Majonga, Andrea M Rehman, Grace McHugh, Hilda A Mujuru, Kusum Nathoo, Mohammad S Patel, Shungu Munyati, Jon O Odland, Katharina Kranzer, Juan P Kaski and 1 more

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Article in International journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Unexpectedly High Prevalence of Cytomegalovirus DNAemia in Older Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edith D MajongaLondon School of Hygiene and Tropical Medicine, London, United Kingdom; Biomedical Research and Training Institute, Harare, Zimbabwe. Electronic address: Edith.Majonga@lshtm.ac.uk.
Andrea M RehmanLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Grace McHughBiomedical Research and Training Institute, Harare, Zimbabwe.
Hilda A MujuruUniversity of Zimbabwe, Harare, Zimbabwe.
Kusum NathooUniversity of Zimbabwe, Harare, Zimbabwe.
Mohammad S PatelMRI & Radiology Centre, Harare, Zimbabwe.
Shungu MunyatiBiomedical Research and Training Institute, Harare, Zimbabwe.
Jon O OdlandUiT, The Arctic University of Norway, Tromsø, Norway; Department of Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Katharina KranzerLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Juan P KaskiCentre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom; Institute of Cardiovascular Science, University College London, United Kingdom.
Rashida A FerrandLondon School of Hygiene and Tropical Medicine, London, United Kingdom; Biomedical Research and Training Institute, Harare, Zimbabwe.

Funding

Medical Research Council MR/K012126/1
6 · The paper itself

Abstract

backgroundEchocardiographic reference ranges are important to identify abnormalities of cardiac dimensions. Reference ranges for children in sub-Saharan Africa have not been established. The aim of this study was to establish echocardiographic z-score references for Black children in sub-Saharan Africa.

methods282 healthy subjects aged 6-16years (143 [51%] males) with no known history of cardiac disease were enrolled in the study in Harare, Zimbabwe between 2014 and 2016. Standard M-mode echocardiography was performed and nine cardiac chamber dimensions were obtained. Two non-linear statistical models (gamma weighted model and cubic polynomial model) were tested on the data and the best fitting model was used to calculate z-scores of these cardiac chamber measures. The reference ranges are presented on scatter plots against BSA.

resultsNormative data for the following cardiac measures were obtained and z-scores calculated: right ventricular diameter at end diastole (RVEDD); left ventricular diameter at end diastole (LVEDD) and systole (LVESD); interventricular septal wall thickness at end diastole (IVSd) and systole (IVSs); left ventricular posterior wall thickness at end diastole (LVPWd) and systole (LVPWs); left atrium diameter at end systole (LA) and tricuspid annular plane systolic excursion (TAPSE). Girls had higher values for BMI and heart rate than boys (p=0.048 and p=0.001, respectively). Mean interventricular septal and left ventricular posterior walls thickness was higher than published normal values in predominantly Caucasian populations.

conclusionThese are the first echocardiographic reference ranges for children from sub Saharan Africa and will allow accurate assessment of cardiac dimensions in clinical practice.

Indexed as

Black PeopleAdolescentAfrica South of the SaharaChildEchocardiographyFemaleHeart DiseasesHumansMaleProspective StudiesReference ValuesAfricaChildrenEchocardiographyReference rangesZ-scores

Identifiers

PMID28711335
PMCPMC5627581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.