ArticleThe Journal of pediatrics2017
Secondhand Smoke Exposure and Preclinical Markers of Cardiovascular Risk in Toddlers.
Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Maternal smoking in pregnancy and blood pressure during childhood and adolescence: a meta-analysis.European journal of pediatrics · 2023Pooled it
- Association of secondhand smoke exposure during pregnancy with left ventricle structure and function in offspring at 4 years old: a prospective birth cohort study.BMC pregnancy and childbirth · 2025Article
- Exposure to air pollution and cardiovascular risk in young children - a pilot project.Pediatric research · 2024Article
- Association of health behaviors in life's essential 8 and hypertension in adolescents: a cross-sectional study from the NHANES database.BMC cardiovascular disorders · 2024Article
- Pre- and postnatal exposure to secondhand tobacco smoke and cardiometabolic risk at 12 years: Periods of susceptibility.Environmental research · 2023Article
- Second-hand smoke exposure in adolescents in Latin America and the Caribbean: a pooled analysis.Lancet regional health. Americas · 2023Article
- Perceptions of parents of under-5-year-old children with pneumonia on the effects of tobacco smoke: a phenomenology study in Manggarai, Eastern Indonesia.Journal of public health research · 2021Article
- Age and environmental exposures influence the fecal bacteriome of young children with cystic fibrosis.Pediatric pulmonology · 2020Article
- Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.International journal of environmental research and public health · 2020Review
- Secondhand smoke exposure and higher blood pressure in children and adolescents participating in NHANES.Preventive medicine · 2020Article
- Passive smoking and cardiometabolic risk factors in Iranian children and adolescents: CASPIAN-V study.Journal of diabetes and metabolic disorders · 2019Article
- Magnitude and Chronicity of Environmental Smoke Exposure Across Infancy and Early Childhood in a Sample of Low-Income Children.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis.Thorax · 2019Article
- Common Injuries and Repair Mechanisms in the Endothelial Lining.Chinese medical journal · 2018Review
- Environmental Tobacco Smoke Exposure at Home and High-Sensitivity C-Reactive Protein Levels in Three-to-Five-Year-Old Children.International journal of environmental research and public health · 2017Article
- Associations between prenatal and postnatal substance exposure and salivary C-reactive protein in early childhood.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate relationships between secondhand smoke exposure in young children and several preclinical markers of cardiovascular risk that have been established as relevant to adult populations. STUDY
designThere were 139 children, 2-5 years of age, enrolled in a cross-sectional study. Secondhand smoke exposure was objectively determined by hair nicotine level; a comprehensive panel of clinical markers (morning blood pressure, fasting glucose and insulin, lipid profiles, inflammation) and research markers (markers of oxidation, endothelial stress, and endothelial repair) of cardiovascular risk status were assessed. Univariate and multivariate linear regression were used to evaluate relationships between secondhand smoke exposure and cardiovascular risk markers.
resultsHair nicotine levels were correlated directly with blood pressure and serum C-reactive protein, and inversely correlated with serum high-density lipoprotein cholesterol and endothelial cell progenitor cell prevalence. In multivariate analyses, these relationships remained when controlled for age, sex, body mass index z-score, maternal education, and method of payment. Additionally, in multivariate analyses, hair nicotine level was significantly negatively correlated with total antioxidant capacity.
conclusionsThese results support the view that secondhand smoke exposure in the very young has a detectable relationship with several markers of cardiovascular risk, long before the emergence of clinical disease. Further studies to define mechanisms and strategies to prevent and mitigate these risks early in life are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.