ReviewImmunologic research2017
IgG4-related disease involving polyserous effusions with elevated serum interleukin-6 levels: a case report and literature review.
Review in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- IgG4-related disease and pleural effusion: a systematic review.Journal of thoracic disease · 2025Review
- IgG4-related diseases involving pleura: a case report and literature review.Frontiers in medicine · 2023Article
- Pericarditis as a manifestation of IgG4-related disease.Rheumatology international · 2022Review
- Refractory IgG4-related Pleural Disease with Chylothorax: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2021Review
- Pleuritis associated with immunoglobulin G4-related disease under normal thoracoscopic findings: a case report.Journal of medical case reports · 2021Article
- IgG4-related pleural disease with aortitis and submandibular glands involvement successfully treated with corticosteroid: case-based review.Rheumatology international · 2020Review
- Thoracoscopic Findings in IgG4-related Pleuritis.Internal medicine (Tokyo, Japan) · 2020Article
- Characteristics of pleural effusion in IgG4-related pleuritis.Respiratory medicine case reports · 2020Article
- IgG4-related disease with elevated adenosine deaminase in pleural effusion diagnosed clinically using thoracoscopy under local anesthesia and FDG-PET-CT.Respiratory medicine case reports · 2020Article
- Elevated CA-125 in IgG4 mesenteritis: a red herring or a disease biomarker? Case report and literature review.Rheumatology international · 2019Review
- Long-term spontaneous remission with active surveillance in IgG4-related pleuritis: A case report and literature review.Respiratory medicine case reports · 2019Article
- Severe refractory TAFRO syndrome requiring continuous renal replacement therapy complicated withRenal replacement therapy · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin G4-related disease (IgG4-RD) is a recently described immune-mediated fibroinflammatory disease with a characteristic histopathologic appearance that can affect various organs. We report a 43-year-old Chinese female patient with IgG4-RD involving polyserous effusions with reports of worsening exertional dyspnea for 3 months. Laboratory blood tests revealed that serum interleukin (IL)-6, carbohydrate antigens (CA-199 and CA-125), and alpha-fetoprotein levels were significantly increased, but serum IgG4 levels were normal. Repeat pleural effusion and ascite analysis showed lymphocyte-predominant exudates. In addition, computed tomography scan showed massive pleural effusion in the right pleural cavity, abdominal effusion, and some pericardial effusion with a partial compression atelectasis. Further, medical thoracoscopy was performed to examine the pleural cavity and found multiple nodules on the pleura and partly thickened pleura with a reddish color. Histopathologic and immunohistochemical examination revealed marked lymphocytes and IgG4-positive plasma cell infiltration. The patient was finally diagnosed with IgG4-RD according to the comprehensive diagnostic criteria, although the patient presented similar serological and pathological manifestations of Castleman disease (CD). Our case suggests that IgG4-RD may be one of the causes of polyserous effusions and shows the difficulties in differentiating between IgG4-RD and CD.
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