ArticleScientific reports2017
Cryo-EM reconstruction of the Cafeteria roenbergensis virus capsid suggests novel assembly pathway for giant viruses.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 50 citations in OpenAlex.
- Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland.eLife · 2025Article
- 20 years of research on giant viruses.Npj viruses · 2025Review
- Electron Tomography as a Tool to Study SARS-CoV-2 Morphology.International journal of molecular sciences · 2024Review
- Subnanometer structure of medusavirus capsid during maturation using cryo-electron microscopy.Journal of virology · 2024Article
- Evolution of exploitation and replication of giant viruses and virophages.Virus evolution · 2024Article
- Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.Nature communications · 2023Article
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- Giant virus biology and diversity in the era of genome-resolved metagenomics.Nature reviews. Microbiology · 2022Review
- Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1.Nature communications · 2022Article
- The Astounding World of Glycans from Giant Viruses.Chemical reviews · 2022Review
- Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins.Scientific reports · 2022Article
- Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses.Journal of virology · 2022Article
- A bag of genes and surprises: Giant viruses continue to fascinate researchers for their role in eukaryote evolution and ecology.EMBO reports · 2021Article
- Scaling relation between genome length and particle size of viruses provides insights into viral life history.iScience · 2021Article
- The Structure of ASFV Advances the Fight against the Disease.Trends in biochemical sciences · 2020Article
- The cryo-EM structure of African swine fever virus unravels a unique architecture comprising two icosahedral protein capsids and two lipoprotein membranes.The Journal of biological chemistry · 2020Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Whereas the protein composition and overall shape of several giant virus capsids have been described, the mechanism by which these large capsids assemble remains enigmatic. Here, we present a reconstruction of the capsid of Cafeteria roenbergensis virus (CroV), one of the largest viruses analyzed by cryo-electron microscopy (cryo-EM) to date. The CroV capsid has a diameter of 3,000 Å and a Triangulation number of 499. Unlike related mimiviruses, the CroV capsid is not decorated with glycosylated surface fibers, but features 30 Å-long surface protrusions that are formed by loops of the major capsid protein. Based on the orientation of capsomers in the cryo-EM reconstruction, we propose that the capsids of CroV and related giant viruses are assembled by a newly conceived assembly pathway that initiates at a five-fold vertex and continuously proceeds outwards in a spiraling fashion.
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