ArticleScientific reports2017
Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- AI-Resolved Protein Energy Landscapes, Electrodynamics, and Fluidic Microcircuits as a Unified Framework for Predicting Neurodegeneration.International journal of molecular sciences · 2026Review
- Practical considerations for accurate estimation of diffusion parameters from single-particle tracking in living cells.The Journal of chemical physics · 2025Article
- Practical considerations for accurate estimation of diffusion parameters from single-particle tracking in living cells.bioRxiv : the preprint server for biology · 2025Article
- Real-space observation of ergodicity transitions in artificial spin ice.Nature communications · 2023Article
- Heterogeneous biological membranes regulate protein partitioning via fluctuating diffusivity.PNAS nexus · 2023Article
- Ensemble heterogeneity mimics ageing for endosomal dynamics within eukaryotic cells.Scientific reports · 2023Article
- Vast heterogeneity in cytoplasmic diffusion rates revealed by nanorheology and Doppelgänger simulations.Biophysical journal · 2023Article
- Non-ergodicity of a globular protein extending beyond its functional timescale.Chemical science · 2022Article
- Regression Analysis of Confocal FRAP and its Application to Diffusion in Membranes.Journal of fluorescence · 2022Article
- Spiracular fluttering decouples oxygen uptake and water loss: a stochastic PDE model of respiratory water loss in insects.Journal of mathematical biology · 2022Article
- Objective comparison of methods to decode anomalous diffusion.Nature communications · 2021Article
- Aging power spectrum of membrane protein transport and other subordinated random walks.Nature communications · 2021Article
- Subtle changes in crosslinking drive diverse anomalous transport characteristics in actin-microtubule networks.Soft matter · 2021Article
- Look at Tempered Subdiffusion in a Conjugate Map: Desire for the Confinement.Entropy (Basel, Switzerland) · 2020Article
- The MAP1B Binding Domain of NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking.Scientific reports · 2019Article
- Identifying diffusive motions in single-particle trajectories on the plasma membrane via fractional time-series models.Physical review. E · 2019Article
- Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability.Scientific reports · 2018Article
- Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk.Nature communications · 2018Article
- Elucidating distinct ion channel populations on the surface of hippocampal neurons via single-particle tracking recurrence analysis.Physical review. E · 2017Article
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7 authors.
Funding
Abstract
Stochastic motion on the surface of living cells is critical to promote molecular encounters that are necessary for multiple cellular processes. Often the complexity of the cell membranes leads to anomalous diffusion, which under certain conditions it is accompanied by non-ergodic dynamics. Here, we unravel two manifestations of ergodicity breaking in the dynamics of membrane proteins in the somatic surface of hippocampal neurons. Three different tagged molecules are studied on the surface of the soma: the voltage-gated potassium and sodium channels Kv1.4 and Nav1.6 and the glycoprotein CD4. In these three molecules ergodicity breaking is unveiled by the confidence interval of the mean square displacement and by the dynamical functional estimator. Ergodicity breaking is found to take place due to transient confinement effects since the molecules alternate between free diffusion and confined motion.
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