ArticleScientific reports2017
Non-ketogenic combination of nutritional strategies provides robust protection against seizures.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Intermittent fasting with medium-chain triglycerides in drug-resistant epilepsy: A pilot crossover trial.Epilepsia · 2026Trial
- Intermittent ketogenic fasting with medium-chain triglycerides improves ataxia in COQ8A-related coenzyme Q10 deficiency: A case report.Molecular genetics and metabolism reports · 2026Article
- The Crucial Interplay Between the Lungs, Brain, and Heart to Understand Epilepsy-Linked SUDEP: A Literature Review.Brain sciences · 2025Review
- Relationship between Dietary Decanoic Acid and Coronary Artery Disease: A Population-Based Cross-Sectional Study.Nutrients · 2023Article
- Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns.PLoS biology · 2022Article
- DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting.Cell reports · 2022Article
- A ketogenic diet protects DBA/1 and Scn1aEpilepsy & behavior : E&B · 2021Article
- Differential ketogenic diet-induced shift in CSF lipid/carbohydrate metabolome of pediatric epilepsy patients with optimal vs. no anticonvulsant response: a pilot study.Nutrition & metabolism · 2021Article
- Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling.Frontiers in molecular neuroscience · 2021Article
- Leucine-Enriched Essential Amino Acids Enhance the Antiseizure Effects of the Ketogenic Diet in Rats.Frontiers in neuroscience · 2021Article
- Microbiota-Gut-Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics.Frontiers in immunology · 2021Review
- Ketone Supplementation: Meeting the Needs of the Brain in an Energy Crisis.Frontiers in nutrition · 2021Review
- Therapeutic Use of the Ketogenic Diet in Refractory Epilepsy: What We Know and What Still Needs to Be Learned.Nutrients · 2020Review
- A ketogenic diet diminishes behavioral responses to cocaine in young adult male and female rats.Neuropharmacology · 2019Article
- Metabolism and epilepsy: Ketogenic diets as a homeostatic link.Brain research · 2019Review
- Time of Day and a Ketogenic Diet Influence Susceptibility to SUDEP inFrontiers in neurology · 2019Article
- Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives.Frontiers in neuroscience · 2019Review
- Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management.Neuropsychiatric disease and treatment · 2019Review
- 2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control.Frontiers in cellular neuroscience · 2019Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a neurological condition that affects 1% of the world population. Conventional treatments of epilepsy use drugs targeting neuronal excitability, inhibitory or excitatory transmission. Yet, one third of patients presents an intractable form of epilepsy and fails to respond to pharmacological anti-epileptic strategies. The ketogenic diet is a well-established non-pharmacological treatment that has been proven to be effective in reducing seizure frequency in the pharmaco-resistant patients. This dietary solution is however extremely restrictive and can be associated with complications caused by the high [fat]:[carbohydrate + protein] ratio. Recent advances suggest that the traditional 4:1 ratio of the ketogenic diet is not a requisite for its therapeutic effect. We show here that combining nutritional strategies targeting specific amino-acids, carbohydrates and fatty acids with a low [fat]:[proteins + carbohydrates] ratio also reduces excitatory drive and protects against seizures to the same extent as the ketogenic diet. Similarly, the morphological and molecular correlates of temporal lobe seizures were reduced in animals fed with the combined diet. These results provide evidence that low-fat dietary strategies more palatable than the ketogenic diet could be useful in epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.