Evidence map›Paper›PMID 28710406›Full record

ArticleScientific reports2017

Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma.

Xiu-Yan Huang, Zi-Li Huang, Yong-Hua Xu, Qi Zheng, Zi Chen, Wei Song, Jian Zhou, Zhao-You Tang, Xin-Yu Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 3 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 3 syntheses or guidelines pooled it, 201 citations in OpenAlex.

  1. Pooled it
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  6. Role of Circular RNAs in Liver Diseases.International journal of medical sciences · 2026
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  17. Virus-Encoded Circular RNAs: Role and Significance in Viral Infections.International journal of molecular sciences · 2023
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Xiu-Yan HuangDepartment of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, P.R. China. xyhuang1119@163.com.
Zi-Li HuangDepartment of Radiology, Xuhui Central Hospital, Shanghai, 200031, P.R. China.
Yong-Hua XuDepartment of Radiology, Xuhui Central Hospital, Shanghai, 200031, P.R. China.
Qi ZhengDepartment of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, P.R. China.
Zi ChenThayer School of Engineering, Norris Cotton Cancer Center, Dartmouth College, Hanover, NH, 03755, USA.
Wei SongHoward Hughes Medical Institute; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Jian ZhouLiver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China.
Zhao-You TangLiver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China.
Xin-Yu HuangDepartment of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, P.R. China. xinyuhuang9@163.com.
Shanghai Sixth People's Hospital · CNShanghai Xuhui Central Hospital · CNDartmouth College · USFudan University · CNHoward Hughes Medical Institute · USZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) represent a class of endogenous noncoding RNAs that have recently been recognized as important regulators of gene expression and pathological networks. However, their transcriptional activities and functional mechanisms in cancer remain largely unknown. Here, we present results from a global circRNA expression and functional analysis of patients with hepatocellular carcinoma (HCC). Using a circRNA microarray, we identified 226 differentially expressed circRNAs, of which 189 were significantly upregulated and 37 were downregulated. High expression of circRNA_100338, one of the upregulated circRNAs in HCC, is closely correlated with a low cumulative survival rate and metastatic progression in HCC patients with hepatitis B. Furthermore, our in silico and experimental analyses identified miR-141-3p as a direct target of circRNA_100338. Thus, circRNA_100338 functions as an endogenous sponge for miR-141-3p in HCC. In addition, we identified the crucial antagonistic roles of circRNA_100338 and miR-141-3p in the regulation of invasive potential in liver cancer cells. Overall, the differential expression of multiple circRNAs in HCC tissues and their clinical significance in hepatitis B-related HCC patients as revealed by our study suggests that circRNA_100338 is a potentially valuable biomarker for HCC diagnosis and target for HCC therapeutics.

Indexed as

Gene Expression ProfilingAgedBase SequenceCarcinoma, HepatocellularFemaleGene Expression Regulation, NeoplasticHepatitis BHumansLiver NeoplasmsMaleMicroRNAsMiddle AgedOligonucleotide Array Sequence AnalysisRNARNA, CircularSequence Homology, Nucleic AcidMicroRNAsMirn140 microRNA, humanRNARNA, Circular

Identifiers

PMID28710406
PMCPMC5511135
OpenAlexW2735049838

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.