ArticleScientific reports2017
Capture of microparticles by bolus flow of red blood cells in capillaries.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Red Blood Cell Distribution and Volume Changes at Capillary Junctions in the Living Human Retina.Investigative ophthalmology & visual science · 2025Article
- Article
- Engineering Synthetic Erythrocytes as Next-Generation Blood Substitutes.Advanced functional materials · 2024Article
- Impact of microparticles released during murine systemic inflammation on macrophage activity and reactive nitrogen species regulation.Immunologic research · 2024Article
- The influence of cell elastic modulus on inertial positions in Poiseuille microflows.Biophysical journal · 2021Article
- Deformation of a Red Blood Cell in a Narrow Rectangular Microchannel.Micromachines · 2019Article
- Accounting for Tube Hematocrit in Modeling of Blood Flow in Cerebral Capillary Networks.Computational and mathematical methods in medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have concluded that microparticles (MPs) can more effectively approach the microvessel wall than nanoparticles because of margination. In this study, however, we show that MPs are not marginated in capillaries where the vessel diameter is comparable to that of red blood cells (RBCs). We numerically investigated the behavior of MPs with a diameter of 1 μm in various microvessel sizes, including capillaries. In capillaries, the flow mode of RBCs shifted from multi-file flow to bolus (single-file) flow, and MPs were captured by the bolus flow of the RBCs instead of being marginated. Once MPs were captured, they rarely escaped from the vortex-like flow structures between RBCs. These capture events were enhanced when the hematocrit was decreased, and reduced when the shear rate was increased. Our results suggest that microparticles may be rather inefficient drug carriers when targeting capillaries because of capture events, but nanoparticles, which are more randomly distributed in capillaries, may be more effective carriers.
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