ArticleScientific reports2017
Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- The undiscovered natural product potential of Actinomycetes.The Journal of antibiotics · 2026Article
- Article
- Annotation of natural product compound families using molecular networking topology and structural similarity fingerprinting.Nature communications · 2023Article
- The Diversity, Metabolomics Profiling, and the Pharmacological Potential of Actinomycetes Isolated from the Estremadura Spur Pockmarks (Portugal).Marine drugs · 2021Article
- Discovery of a Novel LineageInternational journal of microbiology · 2021Article
- Chemical Diversity in a Stingless Bee-Plant Symbiosis.ACS omega · 2019Article
- Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry.Cell chemical biology · 2019Article
- Exploring Actinobacteria Associated With Rhizosphere and Endosphere of the Native Alpine Medicinal PlantFrontiers in microbiology · 2019Article
- Interkingdom microbial consortia mechanisms to guide biotechnological applications.Microbial biotechnology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investigate metabolic exchange in the laboratory is through microbial interactions. Here, we describe the chemical study of selected endophytes isolated from the Brazilian medicinal plant Lychnophora ericoides by pairwise inter-kingdom interactions in order to correlate the impact of co-cultivation to their metabolic profiles. Combining mass spectrometry tools and NMR analyses, a total of 29 compounds were identified. These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and leupeptins chemical families. Two of the identified compounds correspond to a new fungal metabolite (29) and a new actinobacterial angucycline-derivative (23). Our results revealed a substantial arsenal of small molecules induced by microbial interactions, as we begin to unravel the complexity of microbial interactions associated with endophytic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.