ArticleScientific reports2017
Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of Support Vector Machine on fMRI Data as Biomarkers in Schizophrenia Diagnosis: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- An investigation into mental illness and its comorbidities from the perspective of supervenience physicalism.Philosophy, ethics, and humanities in medicine : PEHM · 2025Review
- Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade.Schizophrenia bulletin · 2025Review
- Multi-feature fusion RFE random forest for schizophrenia classification and treatment response prediction.Scientific reports · 2025Article
- Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables.Schizophrenia bulletin · 2024Article
- A spatially constrained independent component analysis jointly informed by structural and functional network connectivity.bioRxiv : the preprint server for biology · 2024Article
- A spatially constrained independent component analysis jointly informed by structural and functional network connectivity.Network neuroscience (Cambridge, Mass.) · 2024Article
- Abnormal Spatial and Temporal Overlap of Time-Varying Brain Functional Networks in Patients with Schizophrenia.Brain sciences · 2023Article
- Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders.NeuroImage · 2023Article
- Brain functional connectivity based on phase lag index of electroencephalography for automated diagnosis of schizophrenia using residual neural networks.Journal of applied clinical medical physics · 2023Article
- Genetic and environmental factors influencing neonatal resting-state functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Large-Scale Thalamocortical Triple Network Dysconnectivities in Patients With First-Episode Psychosis and Individuals at Risk for Psychosis.Schizophrenia bulletin · 2023Article
- Amplitudes of resting-state functional networks - investigation into their correlates and biophysical properties.NeuroImage · 2023Article
- Normative model detects abnormal functional connectivity in psychiatric disorders.Frontiers in psychiatry · 2023Article
- Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity.European archives of psychiatry and clinical neuroscience · 2022Article
- Diagnosis of schizophrenia with functional connectome data: a graph-based convolutional neural network approach.BMC neuroscience · 2022Article
- Article
- Violence, neurocognitive function and clinical correlates in patients with schizophrenia.Frontiers in psychiatry · 2022Article
- The unbalanced reorganization of weaker functional connections induces the altered brain network topology in schizophrenia.Scientific reports · 2021Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of features of brain network connectivity between patients and their first-degree relatives. Independent component analysis was conducted on imaging data collected from 34 healthy controls, 33 schizophrenia patients, and 30 unaffected first-degree relatives. The correlation between functional connectivity with neurocognitive performance and clinical symptoms were calculated. Abnormalities of between-network connectivity largely overlapped in patients and first-degree relatives, but the extent of such abnormalities was relatively minor in relatives. Negative connectivity between language networks and executive control networks was impaired in schizophrenia patients and their first-degree relatives, and this decreased connectivity was correlated with performance in language processing. Similar impairments were found in high-visual network and executive network coupling, and this decreased connection was correlated with the severity of positive symptoms in patients. The results indicated that abnormal functional connectivity within and between perceptual systems (i.e., high-visual and language) and executive control networks was related to the generic risk of schizophrenia, which makes it a potential endophenotype for schizophrenia.
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