Evidence map›Paper›PMID 28710387›Full record

ArticleScientific reports2017

Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.

Kristin M Van Den Ham, Logan K Smith, Martin J Richer, Martin Olivier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kristin M Van Den HamDepartment of Microbiology and Immunology, McGill University, Montréal, QC, H3A 0G4, Canada.
Logan K SmithDepartment of Microbiology and Immunology, McGill University, Montréal, QC, H3A 0G4, Canada.
Martin J RicherDepartment of Microbiology and Immunology, McGill University, Montréal, QC, H3A 0G4, Canada. martin.j.richer@mcgill.ca.
Martin OlivierDepartment of Microbiology and Immunology, McGill University, Montréal, QC, H3A 0G4, Canada. martin.olivier@mcgill.ca.
McGill University · CAMcGill University Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral malaria induced by Plasmodium berghei ANKA infection is dependent on the sequestration of cytotoxic T cells within the brain and augmentation of the inflammatory response. Herein, we demonstrate that inhibition of protein tyrosine phosphatase (PTP) activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology. Mechanistically, the initial upregulation of CXCR3 on splenic T cells upon T cell receptor stimulation was critically decreased through the reduction of T cell-intrinsic PTP activity. Furthermore, PTP inhibition markedly increased IL-10 production by splenic CD4

Indexed as

AnimalsBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesInterleukin-10LiverMalaria, CerebralMice, Inbred C57BLMice, KnockoutOrganometallic CompoundsPhenanthrolinesPlasmodium bergheiProtein Tyrosine PhosphatasesReceptors, Antigen, T-CellReceptors, CXCR3Signal Transductionbisperoxo(1,10-phenanthroline)oxovanadate(1-)Interleukin-10Organometallic CompoundsPhenanthrolinesProtein Tyrosine PhosphatasesReceptors, Antigen, T-CellReceptors, CXCR3

Identifiers

PMID28710387
PMCPMC5511231
OpenAlexW2734515876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.