Evidence map›Paper›PMID 28710382›Full record

ArticleScientific reports2017

Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.

Jing-Ying Chen, Xiao-Xiao He, Chi Ma, Xin-Min Wu, Xi-Lin Wan, Zhen-Kai Xing, Qing-Qing Pei, Xian-Ping Dong, Dong-Xu Liu, Wen-Cheng Xiong and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. KDM5D histone demethylase mediates p38α inactivation via its enzymatic activity to inhibit cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Research progress of the netrins and their receptors in cancer.Journal of cellular and molecular medicine · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime?International journal of molecular sciences · 2021
    Review
  15. Article
  16. Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Jing-Ying ChenKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China.
Xiao-Xiao HeKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China.
Chi MaKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China.
Xin-Min WuDepartment of Neurosurgery, First Hospital of Jilin University, Changchun, China.
Xi-Lin WanKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China.
Zhen-Kai XingKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China.
Qing-Qing PeiKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China.
Xian-Ping DongDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
Dong-Xu LiuSchool of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, 1010, New Zealand.ORCID 0000-0002-5949-7889
Wen-Cheng XiongDepartment of Neuroscience & Regenerative Medicine and Department of Neurology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, USA. wxiong@augusta.edu.
Xiao-Juan ZhuKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024, China. zhuxj720@nenu.edu.cn.
Northeast Normal University · CNAuckland University of Technology · NZAugusta University · USDalhousie University · CAJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas, a common type of brain tumor, are characterized by aggressive infiltration, making it difficultly to cure by surgery. Netrin-1, an extracellular guidance cue critical for neuronal axon path-finding, has been reported to play an important role in cell invasion and migration in several types of cancers. However, the role of netrin-1 in glioma remains largely unknown. Here, we provide evidence suggested that Netrin-1 has a critical role in glioma growth. We found that netrin-1 was significantly increased in glioma samples and positively correlated with cell proliferation, tumor grade and malignancy. Netrin-1 knockdown reduced cell proliferation and attenuated tumor growth in a xenograft mouse model. Further studies found that netrin-1 induced NF-κB p65

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAnimalsBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleGliomaHumansMaleMiceMice, NudeMiddle AgedNeoplasm GradingMYC protein, humanNetrin-1Netrin ReceptorsNF-kappa BNTN1 protein, humanProto-Oncogene Proteins c-mycReceptors, Cell SurfaceRNA, Small InterferingUNC5A protein, human

Identifiers

PMID28710382
PMCPMC5511130
OpenAlexW2736147667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.