Evidence map›Paper›PMID 28710293›Full record

ArticleReproduction (Cambridge, England)2017

Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.

Gervette M Penny, Rebecca B Cochran, Marjut Pihlajoki, Antti Kyrönlahti, Anja Schrade, Merja Häkkinen, Jorma Toppari, Markku Heikinheimo, David B Wilson

Open access · bronzeAbstract read
In one paragraph

Article in Reproduction (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Ultrasound Guided Surgery as a Refinement Tool in Oncology Research.Animals : an open access journal from MDPI · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Mutational analysis of theAsian journal of andrology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Gervette M PennyDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA.
Rebecca B CochranDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA.
Marjut PihlajokiChildren's HospitalUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Antti KyrönlahtiChildren's HospitalUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anja SchradeChildren's HospitalUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Merja HäkkinenUniversity of Eastern FinlandSchool of Pharmacy, Kuopio, Finland.
Jorma ToppariDepartment of PhysiologyInstitute of Biomedicine, University of Turku and Department of Pediatrics, Turku University Hospital, Turku, Finland.
Markku HeikinheimoDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA.
David B WilsonDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA wilson_d@wustl.edu.
St. Louis Children's Hospital · USHelsinki Children's Hospital · FIHelsinki University Hospital · FITurku University Hospital · FIUniversity of Eastern Finland · FIUniversity of Helsinki · FI

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Regulation of Steroidogenic Cell Differentiation in the MouseR01DK075618 · NIDDK · WASHINGTON UNIVERSITY · PI WILSON, DAVID B · 2007 to 2011
$1.4M
NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK075618
6 · The paper itself

Abstract

Testicular Leydig cells produce androgens essential for proper male reproductive development and fertility. Here, we describe a new Leydig cell ablation model based on Cre/Lox recombination of mouse

Indexed as

Genetic VectorsTransduction, Genetic17-Hydroxysteroid DehydrogenasesAdenoviridaeAnimalsCell SurvivalFemaleFertilityGATA4 Transcription FactorGATA6 Transcription FactorGenotypeGonadal Steroid HormonesInsulinIntegrasesLeydig CellsMale17beta-hydroxysteroid dehydrogenase type 317-Hydroxysteroid Dehydrogenases3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomeraseCre recombinaseGata4 protein, mouseGATA4 Transcription FactorGata6 protein, mouseGATA6 Transcription FactorGonadal Steroid HormonesInsulinIntegrasesLeydig insulin-like proteinMultienzyme ComplexesProgesterone ReductaseProteinsSteroid 17-alpha-HydroxylaseSteroid Isomerases

Identifiers

PMID28710293
PMCPMC5589507
OpenAlexW2736232564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.