Evidence map›Paper›PMID 28710091›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Intimal Hyperplasia, Stenosis, and Arteriovenous Fistula Maturation Failure in the Hemodialysis Fistula Maturation Study.

Alfred K Cheung, Peter B Imrey, Charles E Alpers, Michelle L Robbin, Milena Radeva, Brett Larive, Yan-Ting Shiu, Michael Allon, Laura M Dember, Tom Greene and 7 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05654103 (Randomized Controlled Trial Comparing endoAVF Versus surgAVF), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05654103 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Randomized Controlled Trial Comparing endoAVF Versus surgAVF

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled90ConditionsEnd Stage Renal Disease on DialysisArmsendoAVF, surgAVF
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Human Data First: New Biological Premises for Arteriovenous Fistula Research.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The eccentric nature of the neointima.Journal of thrombosis and haemostasis : JTH · 2024
    Article
  19. Article
  20. Vessel wall imaging and quantitative flow assessment in arteriovenous malformations: A feasibility study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 2 countries.

Alfred K CheungDivision of Nephrology and Hypertension, University of Utah, Salt Lake City, Utah; alfred.cheung@hsc.utah.edu.
Peter B ImreyDepartment of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
Charles E AlpersDepartment of Pathology, University of Washington Medical Center, Seattle, Washington.
Michelle L RobbinDepartment of Radiology and.
Milena RadevaDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Brett LariveDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Yan-Ting ShiuDivision of Nephrology and Hypertension, University of Utah, Salt Lake City, Utah.
Michael AllonDivision of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.
Laura M DemberRenal-Electrolyte and Hypertension Division, Department of Medicine.
Tom GreeneDepartment of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, Utah.
Jonathan HimmelfarbDepartment of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington.
Prabir Roy-ChaudhuryDivision of Nephrology, University of Arizona Health Sciences and Banner University Medical Center, Tucson, Arizona.
Christi M TerryDivision of Nephrology and Hypertension, University of Utah, Salt Lake City, Utah.
Miguel A VazquezDivision of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas; and.
John W KusekDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Harold I FeldmanRenal-Electrolyte and Hypertension Division, Department of Medicine.
Hemodialysis Fistula Maturation Study Group
University of Utah · USCenter for Clinical Research (United States) · USCleveland Clinic · USCase Western Reserve University · USNational Institute of Diabetes and Digestive and Kidney Diseases · USSouthern Arizona VA Health Care System · USThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Washington · USUniversity of Washington Medical Center · USVA Salt Lake City Healthcare System · US

Funding

Hemodialysis Fistula Maturation Consortium Data Coordinating CenterU01DK082236 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J · 2008 to 2013
$7.6M
Vascular Structure and Function in Arteriovenous Fistula MaturationU01DK082179 · NIDDK · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2008 to 2012
$2.5M
Determinants of Hemodialysis AV Fistula MaturationU01DK082232 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DEMBER, LAURA M · 2008 to 2012
$2.4M
Modulation of the Hemodynamic Factors Associated with AVF MaturationU01DK082189 · NIDDK · UNIVERSITY OF FLORIDA · PI HUBER, THOMAS S · 2008 to 2012
$1.8M
Anatomic and functional predictors of arteriovenous fistula maturationU01DK082240 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI VAZQUEZ, MIGUEL A · 2008 to 2012
$1.8M
Maturation of Hemodialysis Arteriovenous FistulasU01DK082222 · NIDDK · UNIVERSITY OF UTAH · PI CHEUNG, ALFRED K · 2008 to 2012
$1.8M
Clinical, Hemodynamic and Biological Markers of AV Fistula MaturationU01DK082218 · NIDDK · UNIVERSITY OF CINCINNATI · PI ROY-CHAUDHURY, PRABIR · 2008 to 2012
$1.7M
NIDDK NIH HHS U01 DK082179NIDDK NIH HHS U01 DK082189NIDDK NIH HHS U01 DK082218NIDDK NIH HHS U01 DK082222NIDDK NIH HHS U01 DK082232NIDDK NIH HHS U01 DK082236NIDDK NIH HHS U01 DK082240
6 · The paper itself

Abstract

Intimal hyperplasia and stenosis are often cited as causes of arteriovenous fistula maturation failure, but definitive evidence is lacking. We examined the associations among preexisting venous intimal hyperplasia, fistula venous stenosis after creation, and clinical maturation failure. The Hemodialysis Fistula Maturation Study prospectively observed 602 men and women through arteriovenous fistula creation surgery and their postoperative course. A segment of the vein used to create the fistula was collected intraoperatively for histomorphometric examination. On ultrasounds performed 1 day and 2 and 6 weeks after fistula creation, we assessed fistula venous stenosis using pre-specified criteria on the basis of ratios of luminal diameters and peak blood flow velocities at certain locations along the vessel. We determined fistula clinical maturation using criteria for usability during dialysis. Preexisting venous intimal hyperplasia, expressed per 10% increase in a hyperplasia index (range of 0%-100%), modestly associated with lower fistula blood flow rate (relative change, -2.5%; 95% confidence interval [95% CI], -4.6% to -0.4%;

Indexed as

AdultAgedArteriovenous Shunt, SurgicalConstriction, PathologicFemaleHumansHyperplasiaMaleMiddle AgedPeripheral Vascular DiseasesPostoperative ComplicationsProspective StudiesRegional Blood FlowRenal DialysisTunica IntimaUltrasonography

Identifiers

PMID28710091
PMCPMC5619966
OpenAlexW2734647198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.