Evidence map›Paper›PMID 28710068›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

G

C M Kofron, T Y Kim, M E King, A Xie, F Feng, E Park, Z Qu, B-R Choi, U Mende

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  7. Engineering and Assessing Cardiac Tissue Complexity.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

C M KofronCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
T Y KimCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
M E KingCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
A XieCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
F FengCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
E ParkCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
Z QuDepartment of Medicine, University of California, Los Angeles, California.
B-R ChoiCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and.
U MendeCardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; and ulrike_mende@brown.edu.
Brown University · USRhode Island Hospital · USUniversity of California, Los Angeles · US

Funding

Brown CardioPulmonary Research Training ProgramT32HL094300 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON · 2008 to 2012
$2.2M
Regulation of Gq Signaling in Cardiac Fibroblasts and its Role in Cardiac RemodelR01HL114784 · NHLBI · RHODE ISLAND HOSPITAL · PI MENDE, ULRIKE · 2013 to 2016
$2.0M
Advancing Experimental Models to Study Intercellular Crosstalk of Cardiac CellsR21HL113918 · NHLBI · RHODE ISLAND HOSPITAL · PI MENDE, ULRIKE · 2013 to 2014
$428k
Role of Fibroblasts in Cardiac Remodeling and Regulation of CardiomyocytesF32HL126311 · NHLBI · RHODE ISLAND HOSPITAL · PI KOFRON, CELINDA MICHELLE · 2015 to 2016
$90k
NHLBI NIH HHS F32 HL126311NHLBI NIH HHS R01 HL114784NHLBI NIH HHS R21 HL113918NHLBI NIH HHS T32 HL094300
6 · The paper itself

Abstract

Cardiac fibroblasts (CFs) are known to regulate cardiomyocyte (CM) function in vivo and in two-dimensional in vitro cultures. This study examined the effect of CF activation on the regulation of CM electrical activity in a three-dimensional (3-D) microtissue environment. Using a scaffold-free 3-D platform with interspersed neonatal rat ventricular CMs and CFs, G

Indexed as

Action PotentialsAnimalsAnimals, NewbornConnexin 43ConnexinsFibroblastsGap JunctionsGTP-Binding Protein alpha Subunits, Gq-G11Membrane PotentialsMyocytes, CardiacPatch-Clamp TechniquesRatsRats, Sprague-DawleyConnexin 43connexin 45ConnexinsGTP-Binding Protein alpha Subunits, Gq-G11activated cardiac fibroblastsarrhythmiasautomaticitycardiac myocytesthree-dimensional models

Identifiers

PMID28710068
PMCPMC5668610
OpenAlexW2736211354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.