ArticleImmunity2017
Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals.
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.
- The Breast Milk Immunoglobulinome.Nutrients · 2021Pooled it
- IgM-C4d Complex Causes the Inaccurate Measurement of Serum Uric Acid Levels via the Uricase Method.Current issues in molecular biology · 2026Article
- Immune surveillance and microbial escape in the aging host: Why does the microbiome lose its balance?PLoS biology · 2026Review
- Coexist or eliminate? Antibody-based functional silencing versus eradication in gut microbiome- targeted therapy.Frontiers in immunology · 2026Review
- Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions.Frontiers in microbiology · 2026Review
- Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation.eLife · 2025Article
- Article
- A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut.Nature communications · 2025Article
- HLA-E and NKG2A Mediate Resistance to BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer.bioRxiv : the preprint server for biology · 2025Article
- IgMScientific reports · 2025Article
- Secretory IgM regulates gut microbiota homeostasis and metabolism.Nature microbiology · 2025Article
- Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses.Science advances · 2025Article
- Intestinal immunoglobulins under microbial dysbiosis: implications in opioid-induced microbial dysbiosis.Frontiers in microbiology · 2025Review
- IgG/IgM-coated gut microbiota in schizophrenia: associations with inflammation disease activity.Frontiers in psychiatry · 2025Article
- Gut microbial dysbiosis activates the classical complement pathway in a short-term morphine treatment model.Gut microbes reports · 2025Article
- Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease.The Journal of experimental medicine · 2024Article
- Bridging the gap: Insights in the immunopathology of Lyme borreliosis.European journal of immunology · 2024Review
- Article
- Gastrointestinal germinal center B cell depletion and reduction in IgAScience immunology · 2024Article
- Association between serum IgM and all-cause mortality risk in Chinese centenarians: a prospective cohort study.Immunity & ageing : I & A · 2024Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 4 countries.
Giuliana MagriProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain. Electronic address: gmagri@imim.es.
Laura ComermaProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
Marc PybusProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
Jordi SintesProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
David LligéProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
Daniel Segura-GarzónProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
Sabrina BasconesProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
Ada YesteProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
Emilie K GrassetDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm 171 76, Sweden.
Cindy GutzeitDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mathieu UzzanDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Meera RamanujamImmunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877, USA.
Menno C van ZelmDepartment of Immunology and Pathology, Monash University and Alfred Hospital, Melbourne, VIC 3004, Australia.
Raquel Albero-GonzálezPathology Department, Hospital del Mar, Barcelona 08003, Spain.
Ivonne VazquezPathology Department, Hospital del Mar, Barcelona 08003, Spain.
Mar IglesiasPathology Department, Hospital del Mar, Barcelona 08003, Spain; Universitat Autònoma de Barcelona, Barcelona 08003, Spain.
Sergi SerranoPathology Department, Hospital del Mar, Barcelona 08003, Spain; Universitat Autònoma de Barcelona, Barcelona 08003, Spain.
Lucía MárquezDepartment of Gastroenterology, Hospital del Mar, Barcelona 08003, Spain.
Elena MercadeDepartment of Biology, Health and Environment, University of Barcelona, Barcelona 08028, Spain.
Saurabh MehandruDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Andrea CeruttiProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona 08003, Spain; Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona 08003, Spain. Electronic address: acerutti@imim.es.
Hospital del Mar Research Institute · ESHospital Del Mar · ESIcahn School of Medicine at Mount Sinai · USBoehringer Ingelheim (United States) · USKarolinska University Hospital · SEMonash University · AUUniversitat Autònoma de Barcelona · ESUniversitat de Barcelona · ES
Funding
Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MRegulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3MRegulation and Function of Immunoglobulin D in Mucosal Immune DefenseU01AI095613 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA · 2011 to 2015
$2.1MThe impact of HIV-1 infection and its treatment on gastrointestinal B cellsR01DK112296 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MEHANDRU, SAURABH · 2017 to 2021
$2.0MNIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI057653NIAID NIH HHS U01 AI095613NIDDK NIH HHS R01 DK112296
Abstract
Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM
Indexed as
AdultAgedAged, 80 and overAngiodysplasiaAnimalsB-LymphocytesClone CellsColonic NeoplasmsColonic PolypsFemaleGastrointestinal MicrobiomeHumansImmunity, MucosalImmunoglobulin AImmunoglobulin Class SwitchingImmunoglobulin MImmunoglobulin AImmunoglobulin MguthumanIgAIgMmemory B cellsmicrobiotamucosaplasma cellsrepertoire
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.