Evidence map›Paper›PMID 28709643›Full record

ArticleCellular signalling2017

Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression.

Ali J Zarrabi, Derrick Kao, Dustin T Nguyen, Joseph Loscalzo, Diane E Handy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Bile Acids Alter the Autophagy and Mitogenesis in Skeletal Muscle Cells.Advances in experimental medicine and biology · 2023
    Article
  7. Review
  8. Glycolysis under Circadian Control.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Molecular Crosstalk Between MYC and HIF in Cancer.Frontiers in cell and developmental biology · 2020
    Review
  14. Article
  15. Article
  16. The many lives of Myc in the pancreatic β-cell.The Journal of biological chemistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ali J ZarrabiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Derrick KaoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dustin T NguyenDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Joseph LoscalzoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Diane E HandyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: dhandy@rics.bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Boston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8M
TRANSLATIONAL PHARMACOLOGY COREP50GM107618 · NIGMS · HARVARD MEDICAL SCHOOL · PI GOLAN, DAVID E. · 2014 to 2018
$10.8M
GPx-3 and Peroxide Flux in the Endothelial CellR37HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2007 to 2016
$4.3M
The Phathophenotype Landscape of Complex DiseaseU01HL108630 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2011 to 2014
$2.7M
NHLBI NIH HHS R37 HL061795NHLBI NIH HHS U01 HL108630NHLBI NIH HHS U54 HL119145NIGMS NIH HHS P50 GM107618
6 · The paper itself

Abstract

The adaptive response to hypoxia is mediated in large part by stabilization of the hypoxia-inducible factors, HIF-1α and HIF-2α. A hallmark of this response is the metabolic shift to decreased oxidative phosphorylation and increased glycolysis. We hypothesized that hypoxic responses would include a suppression of mitochondrial gene expression. We determined the effects of hypoxia on TFAM, a key mitochondrial transcription factor, in normal pulmonary artery endothelial cells. Hypoxia decreased gene expression of TFAM and that of its upstream regulator, the transcriptional co-activator PGC1β. Although HIF-1α and HIF-2α pathways both contributed to hypoxia-mediated PGC1β suppression, TFAM suppression was regulated solely by HIF-2α-dependent mechanisms. We found that HIF-2α suppresses TFAM by decreasing c-Myc expression. In addition, we show a role for c-Jun in this pathway, linking HIF-2α with attenuation of c-Jun activation. Taken together, these findings establish a new link between HIF-2α and MAPK-signaling that mediates the adaptive regulation of mitochondrial gene expression under low oxygen tension.

Indexed as

Basic Helix-Loop-Helix ProteinsCarrier ProteinsCell HypoxiaCells, CulturedDNA-Binding ProteinsEndothelial CellsEndothelial PAS Domain-Containing Protein 1Gene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitMitochondrial ProteinsProto-Oncogene Proteins c-junProto-Oncogene Proteins c-mycRNA-Binding ProteinsTranscription FactorsBasic Helix-Loop-Helix ProteinsCarrier ProteinsDNA-Binding ProteinsEndothelial PAS Domain-Containing Protein 1Hypoxia-Inducible Factor 1, alpha SubunitMitochondrial ProteinsPPARGC1B protein, humanProto-Oncogene Proteins c-junProto-Oncogene Proteins c-mycRNA-Binding ProteinsTFAM protein, humanTranscription Factorsc-Junc-MycEndothelial cellsHypoxia inducible factorsTFAM

Identifiers

PMID28709643
PMCPMC5568858
OpenAlexW2735368017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.