Evidence map›Paper›PMID 28709594›Full record

ArticleKidney international2017

Emerging roles of nuclear phosphatase SCP4 in CKD-associated muscle wasting.

Wai W Cheung, Sheng Hao, Robert H Mak

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Metabolites · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Wai W CheungPediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, California, USA.
Sheng HaoPediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, California, USA; Department of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, China.
Robert H MakPediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, California, USA. Electronic address: romak@ucsd.edu.
University of California San Diego · USShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cachexia with wasting of muscle protein is a serious complication of chronic kidney disease (CKD). Muscle protein phosphorylation is a potential therapeutic target. Liu et al. reported that small C-terminal domain phosphatase (SCP) 4 was increased in muscles of patients and mice with CKD. Importantly, knockdown of SCP4 significantly ameliorated muscle wasting in CKD mice. Inhibition of SCP4 may represent a novel therapeutic intervention for muscle wasting in patients with CKD.

Indexed as

Renal Insufficiency, ChronicTranscription FactorsAnimalsHumansMiceMuscle ProteinsMuscular AtrophyPhosphoric Monoester HydrolasesMuscle ProteinsPhosphoric Monoester HydrolasesTranscription Factors

Identifiers

PMID28709594
OpenAlexW2735934747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.