Evidence map›Paper›PMID 28709470›Full record

Trial reportTrials2017

The effects of Cognitive Bias Modification training and oxytocin administration on trust in maternal support: study protocol for a randomized controlled trial.

Martine W F T Verhees, Eva Ceulemans, Marian J Bakermans-Kranenburg, Marinus H van IJzendoorn, Simon de Winter, Guy Bosmans

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02737254 (The Effect of Oxytocin on the Training of Attachment-related Interpretation Bias in Middle Childhood), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02737254 phase4completednot on this map

The Effect of Oxytocin on the Training of Attachment-related Interpretation Bias in Middle Childhood

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2016 to 2016Enrolled100ConditionsTrustArmsOxytocin, Placebo, Secure CBM training, Neutral CBM training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Martine W F T VerheesParenting and Special Education Research Unit, KU Leuven, Leopold Vanderkelenstraat 32, 3000, Leuven, Belgium. martine.verhees@kuleuven.be.ORCID 0000-0001-7471-6341
Eva CeulemansQuantitative Psychology and Individual Differences Research Unit, KU Leuven, Tiensestraat 102, 3000, Leuven, Belgium.
Marian J Bakermans-KranenburgCentre for Child and Family Studies, Leiden University, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands.
Marinus H van IJzendoornCentre for Child and Family Studies, Leiden University, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands.
Simon de WinterParenting and Special Education Research Unit, KU Leuven, Leopold Vanderkelenstraat 32, 3000, Leuven, Belgium.
Guy BosmansParenting and Special Education Research Unit, KU Leuven, Leopold Vanderkelenstraat 32, 3000, Leuven, Belgium.
KU Leuven · BELeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLack of trust in parental support is a transdiagnostic risk factor for the development of psychological problems throughout the lifespan. Research suggests that children's cognitive attachment representations and related information processing biases could be an important target for interventions aiming to build trust in the parent-child relationship. A paradigm that can alter these biases and increase trust is that of Cognitive Bias Modification (CBM), during which a target processing bias is systematically trained. Trust-related CBM training effects could possibly be enhanced by oxytocin, a neuropeptide that has been proposed to play an important role in social information processing and social relationships. The present article describes the study protocol for a double-blind randomized controlled trial (RCT) aimed at testing the individual and combined effects of CBM training and oxytocin administration on trust in maternal support. METHODS/

designOne hundred children (aged 8-12 years) are randomly assigned to one of four intervention conditions. Participants inhale a nasal spray that either contains oxytocin (OT) or a placebo. Additionally, they receive either a CBM training aimed at positively modifying trust-related information processing bias or a neutral placebo training aimed to have no trust-related effects. Main and interaction effects of the interventions are assessed on three levels of trust-related outcome measures: trust-related interpretation bias; self-reported trust; and mother-child interactional behavior. Importantly, side-effects of a single administration of OT in middle childhood are monitored closely to provide further information on the safety of OT administration in this age group. DISCUSSION: The present RCT is the first study to combine CBM training with oxytocin to test for individual and combined effects on trust in mother. If effective, CBM training and oxytocin could be easily applicable and nonintrusive additions to interventions that target trust in the context of the parent-child relationship.

trial registrationClinicalTrials.gov, ID: NCT02737254 . Registered on 23 March 2016.

Indexed as

Maternal BehaviorMother-Child RelationsTrustAdministration, IntranasalAge FactorsBelgiumChildChild BehaviorClinical ProtocolsCognitive Behavioral TherapyDouble-Blind MethodFemaleHumansMaleNeuropsychological TestsObject AttachmentOxytocinAttachmentCognitive Bias Modification (CBM)Interpretation biasMiddle childhoodOxytocinRandomized Controlled Trial (RCT)Trust

Identifiers

PMID28709470
PMCPMC5513044
OpenAlexW2735408374

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.