Evidence map›Paper›PMID 28709466›Full record

Trial reportItalian journal of pediatrics2017

Effects of inhaled hypertonic (7%) saline on lung function test in preschool children with cystic fibrosis: results of a crossover, randomized clinical trial.

Raffaella Nenna, Fabio Midulla, Caterina Lambiase, Giovanna De Castro, Anna Maria Zicari, Luciana Indinnimeo, Giuseppe Cimino, Patrizia Troiani, Serena Quattrucci, Giancarlo Tancredi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Italian journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Nebulised hypertonic saline for cystic fibrosis.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Timing of hypertonic saline inhalation for cystic fibrosis.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Nebulised hypertonic saline for cystic fibrosis.The Cochrane database of systematic reviews · 2018
    Pooled it
  4. Article
  5. Efficacy of hypertonic saline versus isotonic saline among children with cystic fibrosis: A systematic review and meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023
    Review
  6. Article
  7. [Application of a multiple linear regression model of FEV1 in pulmonary function test].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Raffaella NennaDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy. raffaella.nenna@uniroma1.it.ORCID http://orcid.org/0000-0001-8880-3462
Fabio MidullaDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Caterina LambiaseDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Giovanna De CastroDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Anna Maria ZicariDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Luciana IndinnimeoDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Giuseppe CiminoCystic Fibrosis Centre-Department of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Patrizia TroianiCystic Fibrosis Centre-Department of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Serena QuattrucciCystic Fibrosis Centre-Department of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Giancarlo TancrediDepartment of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis crossover, randomized, double-blind study (conducted over a 32-week period) was performed to determine, in clinically stable Cystic fibrosis (CF) preschool children: the effects of 7% inhaled hypertonic saline on spirometry and interrupter resistance technique (Rint), and the possible side effects.

methodsTwelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receive hypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (NS-0.9% sodium chloride) twice a day. After a 16 weeks period, therapy was exchanged to allow all the patients enrolled in the study to carry out both treatments. Monitoring visits, spirometry (COSMED Quark PFT4 ergo) and Rint were scheduled at 0,4,16,20,32 weeks. At T0, spirometric measurements and Rint were performed immediately before and 30 min after the inhalation therapy. Salbutamol (400 mcg) was administered before the drug at each visit.

resultsAfter a 16-weeks treatment with HS an improvement of FVC (p = 0.02) and a favorable trend of FEV1 were registered. A worsening of FEV

conclusionsSeven percent hypertonic saline therapy proved to be a useful and safe treatment in young CF children with clinically stable conditions.

trial registrationISRCTN12345678 .

Indexed as

Administration, InhalationAlbuterolAnti-Asthmatic AgentsChild, PreschoolCross-Over StudiesCystic FibrosisDouble-Blind MethodFemaleHumansMaleRespiratory Function TestsSaline Solution, HypertonicAlbuterolAnti-Asthmatic AgentsSaline Solution, HypertonicChildrenCystic fibrosisHypertonic salineInhalationTherapy

Identifiers

PMID28709466
PMCPMC5512793
OpenAlexW2734674234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.